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Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women

Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima–media thickness, a proxy for subclinical atherosclerosis....

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Autores principales: Iannuzzi, Arcangelo, Giallauria, Francesco, Gentile, Marco, Rubba, Paolo, Covetti, Giuseppe, Bresciani, Alessandro, Aliberti, Emilio, Cuomo, Gilanluigi, Panico, Camilla, Tripaldella, Maria, Giusti, Maria Ausilia, Mattina, Alessandro, Iannuzzo, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745439/
https://www.ncbi.nlm.nih.gov/pubmed/35011818
http://dx.doi.org/10.3390/jcm11010078
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author Iannuzzi, Arcangelo
Giallauria, Francesco
Gentile, Marco
Rubba, Paolo
Covetti, Giuseppe
Bresciani, Alessandro
Aliberti, Emilio
Cuomo, Gilanluigi
Panico, Camilla
Tripaldella, Maria
Giusti, Maria Ausilia
Mattina, Alessandro
Iannuzzo, Gabriella
author_facet Iannuzzi, Arcangelo
Giallauria, Francesco
Gentile, Marco
Rubba, Paolo
Covetti, Giuseppe
Bresciani, Alessandro
Aliberti, Emilio
Cuomo, Gilanluigi
Panico, Camilla
Tripaldella, Maria
Giusti, Maria Ausilia
Mattina, Alessandro
Iannuzzo, Gabriella
author_sort Iannuzzi, Arcangelo
collection PubMed
description Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima–media thickness, a proxy for subclinical atherosclerosis. Lipid parameters from 220 post-menopausal women undergoing ultrasound investigation of the carotid arteries were analysed. Forty-five percent of women showed subclinical atherosclerosis on carotid ultrasound. The mean carotid intima–media thickness was 1.26 ± 0.38 mm. The mean value of the non-HDL-C/HDL-C ratio was 3.1 ± 1.2. Univariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (r = 0.21, p = 0.001). After adjusting for cardiovascular risk factors (age, systolic blood pressure, smoking, body mass index Homeostasis model assessment: insulin resistance and high-sensitivity C-Reactive-Protein), multivariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (β = 0.039, p = 0.04). Logistic regression analysis showed that the highest tertile of the non-HDL-C/HDL-C ratio was associated with the presence of carotid plaques (OR = 3.47, p = 0.003). Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, p < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels.
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spelling pubmed-87454392022-01-11 Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women Iannuzzi, Arcangelo Giallauria, Francesco Gentile, Marco Rubba, Paolo Covetti, Giuseppe Bresciani, Alessandro Aliberti, Emilio Cuomo, Gilanluigi Panico, Camilla Tripaldella, Maria Giusti, Maria Ausilia Mattina, Alessandro Iannuzzo, Gabriella J Clin Med Article Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima–media thickness, a proxy for subclinical atherosclerosis. Lipid parameters from 220 post-menopausal women undergoing ultrasound investigation of the carotid arteries were analysed. Forty-five percent of women showed subclinical atherosclerosis on carotid ultrasound. The mean carotid intima–media thickness was 1.26 ± 0.38 mm. The mean value of the non-HDL-C/HDL-C ratio was 3.1 ± 1.2. Univariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (r = 0.21, p = 0.001). After adjusting for cardiovascular risk factors (age, systolic blood pressure, smoking, body mass index Homeostasis model assessment: insulin resistance and high-sensitivity C-Reactive-Protein), multivariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (β = 0.039, p = 0.04). Logistic regression analysis showed that the highest tertile of the non-HDL-C/HDL-C ratio was associated with the presence of carotid plaques (OR = 3.47, p = 0.003). Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, p < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels. MDPI 2021-12-24 /pmc/articles/PMC8745439/ /pubmed/35011818 http://dx.doi.org/10.3390/jcm11010078 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iannuzzi, Arcangelo
Giallauria, Francesco
Gentile, Marco
Rubba, Paolo
Covetti, Giuseppe
Bresciani, Alessandro
Aliberti, Emilio
Cuomo, Gilanluigi
Panico, Camilla
Tripaldella, Maria
Giusti, Maria Ausilia
Mattina, Alessandro
Iannuzzo, Gabriella
Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
title Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
title_full Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
title_fullStr Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
title_full_unstemmed Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
title_short Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
title_sort association between non-hdl-c/hdl-c ratio and carotid intima–media thickness in post-menopausal women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745439/
https://www.ncbi.nlm.nih.gov/pubmed/35011818
http://dx.doi.org/10.3390/jcm11010078
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