Cargando…

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion

Over the last decades, lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell function in particular. However, these terms hold various potential biological processes, and it is no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oberhauser, Lucie, Maechler, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745448/ https://www.ncbi.nlm.nih.gov/pubmed/35008750 http://dx.doi.org/10.3390/ijms23010324

Ejemplares similares

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
por: Li, Ning, et al.
Publicado: (2017)

The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
por: Yoon, Ji Sung, et al.
Publicado: (2016)

Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells
por: Elumalai, Suma, et al.
Publicado: (2016)

Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells
por: Katsura, Takashi, et al.
Publicado: (2017)

The role of membrane excitability in pancreatic β-cell glucotoxicity
por: Shyr, Zeenat A., et al.
Publicado: (2019)

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress
por: Brun, Thierry, et al.
Publicado: (2020)

Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells
por: Lee, Hae-Jung, et al.
Publicado: (2015)

Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction
por: Shu, Tingting, et al.
Publicado: (2019)

Which Factor Determines the Duration Required for Relief of Glucotoxicity by the Intensive Insulin Therapy?
por: Yanai, Hidekatsu, et al.
Publicado: (2018)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity
por: Chang, Chia-Chuan, et al.
Publicado: (2016)

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress
por: Jimenez-Sánchez, Cecilia, et al.
Publicado: (2020)

Lin28a ameliorates glucotoxicity-induced β-cell dysfunction and apoptosis
por: Hwang, Yeo Jin, et al.
Publicado: (2021)

Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells
por: Grajales, Diana, et al.
Publicado: (2022)

Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions
por: Qian, Y, et al.
Publicado: (2017)

Insulin-producing cells could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells
por: Shi, Qiping, et al.
Publicado: (2013)

Platelet‐derived lipids promote insulin secretion of pancreatic β cells
por: Karwen, Till, et al.
Publicado: (2023)

Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells
por: Cha, Seon-Heui, et al.
Publicado: (2018)

Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway
por: Kong, Xiangchen, et al.
Publicado: (2015)

A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis
por: Li, Yating, et al.
Publicado: (2016)

HM-Chromanone Isolated from Portulaca Oleracea L. Protects INS-1 Pancreatic β Cells against Glucotoxicity-Induced Apoptosis
por: Park, Jae Eun, et al.
Publicado: (2019)

Analyzing the Factors Contributing to Withdrawal from Insulin Therapy Following Additional Administration of Alogliptin: Retrospective Study after Removing Glucotoxicity with Insulin
por: Hamamoto, Hiromi, et al.
Publicado: (2015)

Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions
por: Kwon, Min Jeong, et al.
Publicado: (2013)

Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion
por: Rafacho, Alex, et al.
Publicado: (2015)

Zip4 Mediated Zinc Influx Stimulates Insulin Secretion in Pancreatic Beta Cells
por: Hardy, Alexandre B., et al.
Publicado: (2015)

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion
por: Li, L, et al.
Publicado: (2016)

Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion
por: García-Delgado, Neivys, et al.
Publicado: (2018)

Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications
por: Zheng, Hong, et al.
Publicado: (2016)

Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
por: Pignalosa, Francesca Chiara, et al.
Publicado: (2021)

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy
por: Do, Moon Ho, et al.
Publicado: (2019)

Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca(2+) response to glucose
por: Yanagida, Kazuhiro, et al.
Publicado: (2014)

Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells
por: Hwang, In-Hu, et al.
Publicado: (2016)

Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress
por: Fu, Jingqi, et al.
Publicado: (2010)

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion
por: El Azzouny, Mahmoud, et al.
Publicado: (2016)

Stromal cell derived factor-1alpha protects stem cell derived insulin-producing cells from glucotoxicity under high glucose conditions in-vitro and ameliorates drug induced diabetes in rats
por: Tariq, Muhammad, et al.
Publicado: (2013)

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion
por: Berdous, Dassine, et al.
Publicado: (2020)

Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion
por: Fu, Yi, et al.
Publicado: (2009)

Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion
Publicado: (1992)

Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells
por: Watson, Maria L., et al.
Publicado: (2011)

MiR-190 ameliorates glucotoxicity-induced dysfunction and apoptosis of pancreatic β-cells by inhibiting NOX2-mediated reactive oxygen species production
por: Lu, Huinan, et al.
Publicado: (2022)

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure
por: Kluth, O., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_fhu5odijpsf44slqjlrq96tjcv