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Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases
(1) Background: there are few studies on the inflammation of unknown origin (IUO). We sought to determine the etiologies and prognosis of IUO, as well as the contribution of complementary examinations. (2) Methods: this retrospective study analyzed patients meeting the Vanderschueren’s criteria in t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745449/ https://www.ncbi.nlm.nih.gov/pubmed/35011773 http://dx.doi.org/10.3390/jcm11010032 |
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author | Béra, Suzanne Jamilloux, Yvan Gerfaud-Valentin, Mathieu Durupt, Stéphane Nove-Josserand, Raphaèle Lega, Jean-Christophe Durieu, Isabelle Hot, Arnaud Sève, Pascal |
author_facet | Béra, Suzanne Jamilloux, Yvan Gerfaud-Valentin, Mathieu Durupt, Stéphane Nove-Josserand, Raphaèle Lega, Jean-Christophe Durieu, Isabelle Hot, Arnaud Sève, Pascal |
author_sort | Béra, Suzanne |
collection | PubMed |
description | (1) Background: there are few studies on the inflammation of unknown origin (IUO). We sought to determine the etiologies and prognosis of IUO, as well as the contribution of complementary examinations. (2) Methods: this retrospective study analyzed patients meeting the Vanderschueren’s criteria in the Hospices Civils de Lyon from 2005 to 2020. (3) Results: a total of 57 patients (mean age: 67 years; interquartile range: 55–79) were included. Final diagnoses were made for 26 (46%) patients. Non-infectious inflammatory diseases were the most common diagnoses (13/26, 50%), followed by neoplasms (10/26, 38%; 8/10 hematological malignancies), infections (2/26, 8%), and miscellaneous causes (1/26, 4%). Moreover, 18-FDG-PET/CT was contributory in 12/42 cases. Anti-neutrophil cytoplasmic antibodies, serology, temporal biopsies, and bone marrow aspirates were contributory in 3/41, 1/57, 5/23, and 3/19 cases, respectively. At last follow-up (mean follow-up duration: 48 months), 8/31 undiagnosed patients were cured (five received an empirical treatment), and 5/31 died (one death was related to the empirical treatment). (4) Conclusion: more than half of the IUO remained undiagnosed. Non-infectious inflammatory diseases and hematological malignancies were the most common etiologies. Moreover, 18-FDG-PET/CT had the highest diagnostic value. Most IUO without final diagnosis persisted. The role of empirical treatments remains to be explored. |
format | Online Article Text |
id | pubmed-8745449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87454492022-01-11 Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases Béra, Suzanne Jamilloux, Yvan Gerfaud-Valentin, Mathieu Durupt, Stéphane Nove-Josserand, Raphaèle Lega, Jean-Christophe Durieu, Isabelle Hot, Arnaud Sève, Pascal J Clin Med Article (1) Background: there are few studies on the inflammation of unknown origin (IUO). We sought to determine the etiologies and prognosis of IUO, as well as the contribution of complementary examinations. (2) Methods: this retrospective study analyzed patients meeting the Vanderschueren’s criteria in the Hospices Civils de Lyon from 2005 to 2020. (3) Results: a total of 57 patients (mean age: 67 years; interquartile range: 55–79) were included. Final diagnoses were made for 26 (46%) patients. Non-infectious inflammatory diseases were the most common diagnoses (13/26, 50%), followed by neoplasms (10/26, 38%; 8/10 hematological malignancies), infections (2/26, 8%), and miscellaneous causes (1/26, 4%). Moreover, 18-FDG-PET/CT was contributory in 12/42 cases. Anti-neutrophil cytoplasmic antibodies, serology, temporal biopsies, and bone marrow aspirates were contributory in 3/41, 1/57, 5/23, and 3/19 cases, respectively. At last follow-up (mean follow-up duration: 48 months), 8/31 undiagnosed patients were cured (five received an empirical treatment), and 5/31 died (one death was related to the empirical treatment). (4) Conclusion: more than half of the IUO remained undiagnosed. Non-infectious inflammatory diseases and hematological malignancies were the most common etiologies. Moreover, 18-FDG-PET/CT had the highest diagnostic value. Most IUO without final diagnosis persisted. The role of empirical treatments remains to be explored. MDPI 2021-12-22 /pmc/articles/PMC8745449/ /pubmed/35011773 http://dx.doi.org/10.3390/jcm11010032 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Béra, Suzanne Jamilloux, Yvan Gerfaud-Valentin, Mathieu Durupt, Stéphane Nove-Josserand, Raphaèle Lega, Jean-Christophe Durieu, Isabelle Hot, Arnaud Sève, Pascal Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases |
title | Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases |
title_full | Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases |
title_fullStr | Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases |
title_full_unstemmed | Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases |
title_short | Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases |
title_sort | inflammation of unknown origin: evaluation and prognosis of 57 cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745449/ https://www.ncbi.nlm.nih.gov/pubmed/35011773 http://dx.doi.org/10.3390/jcm11010032 |
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