Cargando…

Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease

The medial temporal lobe memory system has long been identified as the brain region showing the first histopathological changes in early Alzheimer’s disease (AD), and the functional decline observed in patients also points to a loss of function in this brain area. Nonetheless, the exact identity of...

Descripción completa

Detalles Bibliográficos
Autor principal: Kovács, Krisztián A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745479/
https://www.ncbi.nlm.nih.gov/pubmed/35008886
http://dx.doi.org/10.3390/ijms23010462
_version_ 1784630355380142080
author Kovács, Krisztián A.
author_facet Kovács, Krisztián A.
author_sort Kovács, Krisztián A.
collection PubMed
description The medial temporal lobe memory system has long been identified as the brain region showing the first histopathological changes in early Alzheimer’s disease (AD), and the functional decline observed in patients also points to a loss of function in this brain area. Nonetheless, the exact identity of the neurons and networks that undergo deterioration has not been determined so far. A recent study has identified the entorhinal and hippocampal neural circuits responsible for encoding new episodic memories. Using this novel model we describe the elements of the episodic memory network that are especially vulnerable in early AD. We provide a hypothesis of how reduced reelin signaling within such a network can promote AD-related changes. Establishing novel associations and creating a temporal structure for new episodic memories are both affected in AD. Here, we furnish a reasonable explanation for both of these previous observations.
format Online
Article
Text
id pubmed-8745479
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87454792022-01-11 Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease Kovács, Krisztián A. Int J Mol Sci Hypothesis The medial temporal lobe memory system has long been identified as the brain region showing the first histopathological changes in early Alzheimer’s disease (AD), and the functional decline observed in patients also points to a loss of function in this brain area. Nonetheless, the exact identity of the neurons and networks that undergo deterioration has not been determined so far. A recent study has identified the entorhinal and hippocampal neural circuits responsible for encoding new episodic memories. Using this novel model we describe the elements of the episodic memory network that are especially vulnerable in early AD. We provide a hypothesis of how reduced reelin signaling within such a network can promote AD-related changes. Establishing novel associations and creating a temporal structure for new episodic memories are both affected in AD. Here, we furnish a reasonable explanation for both of these previous observations. MDPI 2021-12-31 /pmc/articles/PMC8745479/ /pubmed/35008886 http://dx.doi.org/10.3390/ijms23010462 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hypothesis
Kovács, Krisztián A.
Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease
title Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease
title_full Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease
title_fullStr Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease
title_full_unstemmed Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease
title_short Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease
title_sort relevance of a novel circuit-level model of episodic memories to alzheimer’s disease
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745479/
https://www.ncbi.nlm.nih.gov/pubmed/35008886
http://dx.doi.org/10.3390/ijms23010462
work_keys_str_mv AT kovacskrisztiana relevanceofanovelcircuitlevelmodelofepisodicmemoriestoalzheimersdisease