Cargando…
Fecal Calprotectin Is Increased in Stroke
Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut axis has recently gained much attention. Our study aimed...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745495/ https://www.ncbi.nlm.nih.gov/pubmed/35011900 http://dx.doi.org/10.3390/jcm11010159 |
_version_ | 1784630358900211712 |
---|---|
author | Park, Shin Young Lee, Sang Pyung Kim, Woo Jin |
author_facet | Park, Shin Young Lee, Sang Pyung Kim, Woo Jin |
author_sort | Park, Shin Young |
collection | PubMed |
description | Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut axis has recently gained much attention. Our study aimed to evaluate gut inflammation and its association with blood variables in stroke using fecal calprotectin (FC). Methods: Fecal samples were obtained from 27 stroke patients and 27 control subjects. FC was quantitatively measured using a commercial ELISA. Laboratory data on the fecal sample collection were also collected, including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP. Results: There was a significant increase in FC levels in stroke patients compared to the controls. Furthermore, FC in stroke patients was negatively correlated with the Glasgow Coma Scale. Moreover, FC in stroke patients was positively correlated with CRP and negatively correlated with lymphocyte count and albumin. Conclusions: Our findings show that increased FC is associated with consciousness and systemic response in stroke and warrants further studies to elucidate the usefulness of FC in the management of stroke. |
format | Online Article Text |
id | pubmed-8745495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87454952022-01-11 Fecal Calprotectin Is Increased in Stroke Park, Shin Young Lee, Sang Pyung Kim, Woo Jin J Clin Med Article Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut axis has recently gained much attention. Our study aimed to evaluate gut inflammation and its association with blood variables in stroke using fecal calprotectin (FC). Methods: Fecal samples were obtained from 27 stroke patients and 27 control subjects. FC was quantitatively measured using a commercial ELISA. Laboratory data on the fecal sample collection were also collected, including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP. Results: There was a significant increase in FC levels in stroke patients compared to the controls. Furthermore, FC in stroke patients was negatively correlated with the Glasgow Coma Scale. Moreover, FC in stroke patients was positively correlated with CRP and negatively correlated with lymphocyte count and albumin. Conclusions: Our findings show that increased FC is associated with consciousness and systemic response in stroke and warrants further studies to elucidate the usefulness of FC in the management of stroke. MDPI 2021-12-29 /pmc/articles/PMC8745495/ /pubmed/35011900 http://dx.doi.org/10.3390/jcm11010159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Park, Shin Young Lee, Sang Pyung Kim, Woo Jin Fecal Calprotectin Is Increased in Stroke |
title | Fecal Calprotectin Is Increased in Stroke |
title_full | Fecal Calprotectin Is Increased in Stroke |
title_fullStr | Fecal Calprotectin Is Increased in Stroke |
title_full_unstemmed | Fecal Calprotectin Is Increased in Stroke |
title_short | Fecal Calprotectin Is Increased in Stroke |
title_sort | fecal calprotectin is increased in stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745495/ https://www.ncbi.nlm.nih.gov/pubmed/35011900 http://dx.doi.org/10.3390/jcm11010159 |
work_keys_str_mv | AT parkshinyoung fecalcalprotectinisincreasedinstroke AT leesangpyung fecalcalprotectinisincreasedinstroke AT kimwoojin fecalcalprotectinisincreasedinstroke |