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Fecal Calprotectin Is Increased in Stroke

Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut axis has recently gained much attention. Our study aimed...

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Autores principales: Park, Shin Young, Lee, Sang Pyung, Kim, Woo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745495/
https://www.ncbi.nlm.nih.gov/pubmed/35011900
http://dx.doi.org/10.3390/jcm11010159
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author Park, Shin Young
Lee, Sang Pyung
Kim, Woo Jin
author_facet Park, Shin Young
Lee, Sang Pyung
Kim, Woo Jin
author_sort Park, Shin Young
collection PubMed
description Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut axis has recently gained much attention. Our study aimed to evaluate gut inflammation and its association with blood variables in stroke using fecal calprotectin (FC). Methods: Fecal samples were obtained from 27 stroke patients and 27 control subjects. FC was quantitatively measured using a commercial ELISA. Laboratory data on the fecal sample collection were also collected, including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP. Results: There was a significant increase in FC levels in stroke patients compared to the controls. Furthermore, FC in stroke patients was negatively correlated with the Glasgow Coma Scale. Moreover, FC in stroke patients was positively correlated with CRP and negatively correlated with lymphocyte count and albumin. Conclusions: Our findings show that increased FC is associated with consciousness and systemic response in stroke and warrants further studies to elucidate the usefulness of FC in the management of stroke.
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spelling pubmed-87454952022-01-11 Fecal Calprotectin Is Increased in Stroke Park, Shin Young Lee, Sang Pyung Kim, Woo Jin J Clin Med Article Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut axis has recently gained much attention. Our study aimed to evaluate gut inflammation and its association with blood variables in stroke using fecal calprotectin (FC). Methods: Fecal samples were obtained from 27 stroke patients and 27 control subjects. FC was quantitatively measured using a commercial ELISA. Laboratory data on the fecal sample collection were also collected, including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP. Results: There was a significant increase in FC levels in stroke patients compared to the controls. Furthermore, FC in stroke patients was negatively correlated with the Glasgow Coma Scale. Moreover, FC in stroke patients was positively correlated with CRP and negatively correlated with lymphocyte count and albumin. Conclusions: Our findings show that increased FC is associated with consciousness and systemic response in stroke and warrants further studies to elucidate the usefulness of FC in the management of stroke. MDPI 2021-12-29 /pmc/articles/PMC8745495/ /pubmed/35011900 http://dx.doi.org/10.3390/jcm11010159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Shin Young
Lee, Sang Pyung
Kim, Woo Jin
Fecal Calprotectin Is Increased in Stroke
title Fecal Calprotectin Is Increased in Stroke
title_full Fecal Calprotectin Is Increased in Stroke
title_fullStr Fecal Calprotectin Is Increased in Stroke
title_full_unstemmed Fecal Calprotectin Is Increased in Stroke
title_short Fecal Calprotectin Is Increased in Stroke
title_sort fecal calprotectin is increased in stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745495/
https://www.ncbi.nlm.nih.gov/pubmed/35011900
http://dx.doi.org/10.3390/jcm11010159
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