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COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients’ management in Southern Italy in the period February 2020–January 2021. This population-based cohort study was conducted using COVID-19 surveil...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745524/ https://www.ncbi.nlm.nih.gov/pubmed/35011810 http://dx.doi.org/10.3390/jcm11010051 |
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author | Crisafulli, Salvatore Ientile, Valentina L’Abbate, Luca Fontana, Andrea Linguiti, Claudio Manna, Sonia Mercaldo, Mariangela Pagliaro, Claudia Vezzaro, Michele Santacà, Katia Lora, Riccardo Moretti, Ugo Reno, Chiara Fantini, Maria Pia Corrao, Salvatore Barbato, Donato Tari, Michele Trifirò, Gianluca |
author_facet | Crisafulli, Salvatore Ientile, Valentina L’Abbate, Luca Fontana, Andrea Linguiti, Claudio Manna, Sonia Mercaldo, Mariangela Pagliaro, Claudia Vezzaro, Michele Santacà, Katia Lora, Riccardo Moretti, Ugo Reno, Chiara Fantini, Maria Pia Corrao, Salvatore Barbato, Donato Tari, Michele Trifirò, Gianluca |
author_sort | Crisafulli, Salvatore |
collection | PubMed |
description | Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients’ management in Southern Italy in the period February 2020–January 2021. This population-based cohort study was conducted using COVID-19 surveillance registry from Caserta Local Health Unit, which was linked to claims databases from the same catchment area. The date of SARS-CoV-2 infection diagnosis was the index date (ID). We evaluated demographic and clinical characteristics of the study drug users and the pattern of use of drugs prescribed for outpatient COVID-19 management. Overall, 40,030 patients were included in the analyses, with a median (IQR) age of 44 (27–58) years. More than half of the included patients were asymptomatic at the ID. Overall, during the study period, 720 (1.8%) patients died due to COVID-19. Azithromycin and glucocorticoids were the most frequently prescribed drugs, while oxygen was the less frequently prescribed therapy. The cumulative rate of recovery from COVID-19 was 84.2% at 30 days from ID and it was lower among older patients. In this study we documented that the drug prescribing patterns for COVID-19 treatment in an outpatient setting from Southern Italy was not supported from current evidence on beneficial therapies for early treatment of COVID-19, thus highlighting the need to implement strategies for improving appropriate drug prescribing in general practice. |
format | Online Article Text |
id | pubmed-8745524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87455242022-01-11 COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy Crisafulli, Salvatore Ientile, Valentina L’Abbate, Luca Fontana, Andrea Linguiti, Claudio Manna, Sonia Mercaldo, Mariangela Pagliaro, Claudia Vezzaro, Michele Santacà, Katia Lora, Riccardo Moretti, Ugo Reno, Chiara Fantini, Maria Pia Corrao, Salvatore Barbato, Donato Tari, Michele Trifirò, Gianluca J Clin Med Article Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients’ management in Southern Italy in the period February 2020–January 2021. This population-based cohort study was conducted using COVID-19 surveillance registry from Caserta Local Health Unit, which was linked to claims databases from the same catchment area. The date of SARS-CoV-2 infection diagnosis was the index date (ID). We evaluated demographic and clinical characteristics of the study drug users and the pattern of use of drugs prescribed for outpatient COVID-19 management. Overall, 40,030 patients were included in the analyses, with a median (IQR) age of 44 (27–58) years. More than half of the included patients were asymptomatic at the ID. Overall, during the study period, 720 (1.8%) patients died due to COVID-19. Azithromycin and glucocorticoids were the most frequently prescribed drugs, while oxygen was the less frequently prescribed therapy. The cumulative rate of recovery from COVID-19 was 84.2% at 30 days from ID and it was lower among older patients. In this study we documented that the drug prescribing patterns for COVID-19 treatment in an outpatient setting from Southern Italy was not supported from current evidence on beneficial therapies for early treatment of COVID-19, thus highlighting the need to implement strategies for improving appropriate drug prescribing in general practice. MDPI 2021-12-23 /pmc/articles/PMC8745524/ /pubmed/35011810 http://dx.doi.org/10.3390/jcm11010051 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Crisafulli, Salvatore Ientile, Valentina L’Abbate, Luca Fontana, Andrea Linguiti, Claudio Manna, Sonia Mercaldo, Mariangela Pagliaro, Claudia Vezzaro, Michele Santacà, Katia Lora, Riccardo Moretti, Ugo Reno, Chiara Fantini, Maria Pia Corrao, Salvatore Barbato, Donato Tari, Michele Trifirò, Gianluca COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy |
title | COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy |
title_full | COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy |
title_fullStr | COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy |
title_full_unstemmed | COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy |
title_short | COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy |
title_sort | covid-19 patient management in outpatient setting: a population-based study from southern italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745524/ https://www.ncbi.nlm.nih.gov/pubmed/35011810 http://dx.doi.org/10.3390/jcm11010051 |
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