Cargando…

COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy

Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients’ management in Southern Italy in the period February 2020–January 2021. This population-based cohort study was conducted using COVID-19 surveil...

Descripción completa

Detalles Bibliográficos
Autores principales: Crisafulli, Salvatore, Ientile, Valentina, L’Abbate, Luca, Fontana, Andrea, Linguiti, Claudio, Manna, Sonia, Mercaldo, Mariangela, Pagliaro, Claudia, Vezzaro, Michele, Santacà, Katia, Lora, Riccardo, Moretti, Ugo, Reno, Chiara, Fantini, Maria Pia, Corrao, Salvatore, Barbato, Donato, Tari, Michele, Trifirò, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745524/
https://www.ncbi.nlm.nih.gov/pubmed/35011810
http://dx.doi.org/10.3390/jcm11010051
_version_ 1784630365963419648
author Crisafulli, Salvatore
Ientile, Valentina
L’Abbate, Luca
Fontana, Andrea
Linguiti, Claudio
Manna, Sonia
Mercaldo, Mariangela
Pagliaro, Claudia
Vezzaro, Michele
Santacà, Katia
Lora, Riccardo
Moretti, Ugo
Reno, Chiara
Fantini, Maria Pia
Corrao, Salvatore
Barbato, Donato
Tari, Michele
Trifirò, Gianluca
author_facet Crisafulli, Salvatore
Ientile, Valentina
L’Abbate, Luca
Fontana, Andrea
Linguiti, Claudio
Manna, Sonia
Mercaldo, Mariangela
Pagliaro, Claudia
Vezzaro, Michele
Santacà, Katia
Lora, Riccardo
Moretti, Ugo
Reno, Chiara
Fantini, Maria Pia
Corrao, Salvatore
Barbato, Donato
Tari, Michele
Trifirò, Gianluca
author_sort Crisafulli, Salvatore
collection PubMed
description Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients’ management in Southern Italy in the period February 2020–January 2021. This population-based cohort study was conducted using COVID-19 surveillance registry from Caserta Local Health Unit, which was linked to claims databases from the same catchment area. The date of SARS-CoV-2 infection diagnosis was the index date (ID). We evaluated demographic and clinical characteristics of the study drug users and the pattern of use of drugs prescribed for outpatient COVID-19 management. Overall, 40,030 patients were included in the analyses, with a median (IQR) age of 44 (27–58) years. More than half of the included patients were asymptomatic at the ID. Overall, during the study period, 720 (1.8%) patients died due to COVID-19. Azithromycin and glucocorticoids were the most frequently prescribed drugs, while oxygen was the less frequently prescribed therapy. The cumulative rate of recovery from COVID-19 was 84.2% at 30 days from ID and it was lower among older patients. In this study we documented that the drug prescribing patterns for COVID-19 treatment in an outpatient setting from Southern Italy was not supported from current evidence on beneficial therapies for early treatment of COVID-19, thus highlighting the need to implement strategies for improving appropriate drug prescribing in general practice.
format Online
Article
Text
id pubmed-8745524
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87455242022-01-11 COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy Crisafulli, Salvatore Ientile, Valentina L’Abbate, Luca Fontana, Andrea Linguiti, Claudio Manna, Sonia Mercaldo, Mariangela Pagliaro, Claudia Vezzaro, Michele Santacà, Katia Lora, Riccardo Moretti, Ugo Reno, Chiara Fantini, Maria Pia Corrao, Salvatore Barbato, Donato Tari, Michele Trifirò, Gianluca J Clin Med Article Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients’ management in Southern Italy in the period February 2020–January 2021. This population-based cohort study was conducted using COVID-19 surveillance registry from Caserta Local Health Unit, which was linked to claims databases from the same catchment area. The date of SARS-CoV-2 infection diagnosis was the index date (ID). We evaluated demographic and clinical characteristics of the study drug users and the pattern of use of drugs prescribed for outpatient COVID-19 management. Overall, 40,030 patients were included in the analyses, with a median (IQR) age of 44 (27–58) years. More than half of the included patients were asymptomatic at the ID. Overall, during the study period, 720 (1.8%) patients died due to COVID-19. Azithromycin and glucocorticoids were the most frequently prescribed drugs, while oxygen was the less frequently prescribed therapy. The cumulative rate of recovery from COVID-19 was 84.2% at 30 days from ID and it was lower among older patients. In this study we documented that the drug prescribing patterns for COVID-19 treatment in an outpatient setting from Southern Italy was not supported from current evidence on beneficial therapies for early treatment of COVID-19, thus highlighting the need to implement strategies for improving appropriate drug prescribing in general practice. MDPI 2021-12-23 /pmc/articles/PMC8745524/ /pubmed/35011810 http://dx.doi.org/10.3390/jcm11010051 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crisafulli, Salvatore
Ientile, Valentina
L’Abbate, Luca
Fontana, Andrea
Linguiti, Claudio
Manna, Sonia
Mercaldo, Mariangela
Pagliaro, Claudia
Vezzaro, Michele
Santacà, Katia
Lora, Riccardo
Moretti, Ugo
Reno, Chiara
Fantini, Maria Pia
Corrao, Salvatore
Barbato, Donato
Tari, Michele
Trifirò, Gianluca
COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
title COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
title_full COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
title_fullStr COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
title_full_unstemmed COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
title_short COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
title_sort covid-19 patient management in outpatient setting: a population-based study from southern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745524/
https://www.ncbi.nlm.nih.gov/pubmed/35011810
http://dx.doi.org/10.3390/jcm11010051
work_keys_str_mv AT crisafullisalvatore covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT ientilevalentina covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT labbateluca covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT fontanaandrea covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT linguiticlaudio covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT mannasonia covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT mercaldomariangela covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT pagliaroclaudia covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT vezzaromichele covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT santacakatia covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT lorariccardo covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT morettiugo covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT renochiara covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT fantinimariapia covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT corraosalvatore covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT barbatodonato covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT tarimichele covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT trifirogianluca covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly
AT covid19patientmanagementinoutpatientsettingapopulationbasedstudyfromsouthernitaly