Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice

Oncostatin M (OSM) and leukemia inhibitory factor (LIF) signaling protects the heart after myocardial infarction (MI). In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the respective cognate ligands while OSM activates both the OSMR an...

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Detalles Bibliográficos
Autores principales: Lörchner, Holger, Adrian-Segarra, Juan M., Waechter, Christian, Wagner, Roxanne, Góes, Maria Elisa, Brachmann, Nathalie, Sreenivasan, Krishnamoorthy, Wietelmann, Astrid, Günther, Stefan, Doll, Nicolas, Braun, Thomas, Pöling, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745562/
https://www.ncbi.nlm.nih.gov/pubmed/35008777
http://dx.doi.org/10.3390/ijms23010353

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