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Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins
Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and oth...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745587/ https://www.ncbi.nlm.nih.gov/pubmed/35008987 http://dx.doi.org/10.3390/ijms23010562 |
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author | Carey, Jannette |
author_facet | Carey, Jannette |
author_sort | Carey, Jannette |
collection | PubMed |
description | Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and others, constitute the vast majority of biology at the molecular level. An understanding of those interactions requires that we quantify them to learn how they interact: How strongly? With which partners? How—and how well—are different partners distinguished? This review addresses the evolution of our current understanding of the molecular origins of affinity and specificity in regulatory protein–DNA interactions, and suggests that both these properties can be modulated by cooperativity. |
format | Online Article Text |
id | pubmed-8745587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87455872022-01-11 Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins Carey, Jannette Int J Mol Sci Review Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and others, constitute the vast majority of biology at the molecular level. An understanding of those interactions requires that we quantify them to learn how they interact: How strongly? With which partners? How—and how well—are different partners distinguished? This review addresses the evolution of our current understanding of the molecular origins of affinity and specificity in regulatory protein–DNA interactions, and suggests that both these properties can be modulated by cooperativity. MDPI 2022-01-05 /pmc/articles/PMC8745587/ /pubmed/35008987 http://dx.doi.org/10.3390/ijms23010562 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carey, Jannette Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
title | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
title_full | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
title_fullStr | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
title_full_unstemmed | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
title_short | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
title_sort | affinity, specificity, and cooperativity of dna binding by bacterial gene regulatory proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745587/ https://www.ncbi.nlm.nih.gov/pubmed/35008987 http://dx.doi.org/10.3390/ijms23010562 |
work_keys_str_mv | AT careyjannette affinityspecificityandcooperativityofdnabindingbybacterialgeneregulatoryproteins |