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Structure–Function Relationships in the Human P-Glycoprotein (ABCB1): Insights from Molecular Dynamics Simulations

P-Glycoprotein (P-gp) is a transmembrane protein belonging to the ATP binding cassette superfamily of transporters, and it is a xenobiotic efflux pump that limits intracellular drug accumulation by pumping compounds out of cells. P-gp contributes to a reduction in toxicity, and has broad substrate s...

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Detalles Bibliográficos
Autores principales: Mora Lagares, Liadys, Pérez-Castillo, Yunierkis, Minovski, Nikola, Novič, Marjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745603/
https://www.ncbi.nlm.nih.gov/pubmed/35008783
http://dx.doi.org/10.3390/ijms23010362