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Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic

(1) Background: There are limited clinical data in patients from the Eastern European regions hospitalized for a severe form of Coronavirus disease 2019 (COVID-19). This study aims to identify risk factors associated with intra-hospital mortality in patients with COVID-19 severe pneumonia admitted t...

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Autores principales: Timpau, Amalia-Stefana, Miftode, Radu-Stefan, Petris, Antoniu Octavian, Costache, Irina-Iuliana, Miftode, Ionela-Larisa, Rosu, Florin Manuel, Anton-Paduraru, Dana-Teodora, Leca, Daniela, Miftode, Egidia Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745635/
https://www.ncbi.nlm.nih.gov/pubmed/35011795
http://dx.doi.org/10.3390/jcm11010058
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author Timpau, Amalia-Stefana
Miftode, Radu-Stefan
Petris, Antoniu Octavian
Costache, Irina-Iuliana
Miftode, Ionela-Larisa
Rosu, Florin Manuel
Anton-Paduraru, Dana-Teodora
Leca, Daniela
Miftode, Egidia Gabriela
author_facet Timpau, Amalia-Stefana
Miftode, Radu-Stefan
Petris, Antoniu Octavian
Costache, Irina-Iuliana
Miftode, Ionela-Larisa
Rosu, Florin Manuel
Anton-Paduraru, Dana-Teodora
Leca, Daniela
Miftode, Egidia Gabriela
author_sort Timpau, Amalia-Stefana
collection PubMed
description (1) Background: There are limited clinical data in patients from the Eastern European regions hospitalized for a severe form of Coronavirus disease 2019 (COVID-19). This study aims to identify risk factors associated with intra-hospital mortality in patients with COVID-19 severe pneumonia admitted to a tertiary center in Iasi, Romania. (2) Methods: The study is of a unicentric retrospective observational type and includes 150 patients with severe COVID-19 pneumonia divided into two subgroups, survivors and non-survivors. Demographic and clinical parameters, as well as comorbidities, laboratory and imaging investigations upon admission, treatments, and evolution during hospitalization were recorded. First, we sought to identify the risk factors associated with intra-hospital mortality using logistic regression. Secondly, we assessed the correlations between D-Dimer and C-reactive protein and predictors of poor prognosis. (3) Results: The predictors of in-hospital mortality identified in the study are D-dimers >0.5 mg/L (p = 0.002), C-reactive protein >5 mg/L (p = 0.001), and heart rate above 100 beats per minute (p = 0.001). The biomarkers were also significantly correlated the need for mechanical ventilation, admission to intensive care unit, or multiple organ dysfunction syndrome. By area under the curve (AUC) analysis, we noticed that both D-Dimer (AUC 0.741) and C-reactive protein (AUC 0.707) exhibit adequate performance in predicting a poor prognosis in patients with severe viral infection. (4) Conclusions: COVID-19′s outcome is significantly influenced by several laboratory and clinical factors. As mortality induced by severe COVID-19 pneumonia is considerable, the identification of risk factors associated with negative outcome coupled with an early therapeutic approach are of paramount importance, as they may significantly improve the outcome and survival rates.
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spelling pubmed-87456352022-01-11 Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic Timpau, Amalia-Stefana Miftode, Radu-Stefan Petris, Antoniu Octavian Costache, Irina-Iuliana Miftode, Ionela-Larisa Rosu, Florin Manuel Anton-Paduraru, Dana-Teodora Leca, Daniela Miftode, Egidia Gabriela J Clin Med Article (1) Background: There are limited clinical data in patients from the Eastern European regions hospitalized for a severe form of Coronavirus disease 2019 (COVID-19). This study aims to identify risk factors associated with intra-hospital mortality in patients with COVID-19 severe pneumonia admitted to a tertiary center in Iasi, Romania. (2) Methods: The study is of a unicentric retrospective observational type and includes 150 patients with severe COVID-19 pneumonia divided into two subgroups, survivors and non-survivors. Demographic and clinical parameters, as well as comorbidities, laboratory and imaging investigations upon admission, treatments, and evolution during hospitalization were recorded. First, we sought to identify the risk factors associated with intra-hospital mortality using logistic regression. Secondly, we assessed the correlations between D-Dimer and C-reactive protein and predictors of poor prognosis. (3) Results: The predictors of in-hospital mortality identified in the study are D-dimers >0.5 mg/L (p = 0.002), C-reactive protein >5 mg/L (p = 0.001), and heart rate above 100 beats per minute (p = 0.001). The biomarkers were also significantly correlated the need for mechanical ventilation, admission to intensive care unit, or multiple organ dysfunction syndrome. By area under the curve (AUC) analysis, we noticed that both D-Dimer (AUC 0.741) and C-reactive protein (AUC 0.707) exhibit adequate performance in predicting a poor prognosis in patients with severe viral infection. (4) Conclusions: COVID-19′s outcome is significantly influenced by several laboratory and clinical factors. As mortality induced by severe COVID-19 pneumonia is considerable, the identification of risk factors associated with negative outcome coupled with an early therapeutic approach are of paramount importance, as they may significantly improve the outcome and survival rates. MDPI 2021-12-23 /pmc/articles/PMC8745635/ /pubmed/35011795 http://dx.doi.org/10.3390/jcm11010058 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Timpau, Amalia-Stefana
Miftode, Radu-Stefan
Petris, Antoniu Octavian
Costache, Irina-Iuliana
Miftode, Ionela-Larisa
Rosu, Florin Manuel
Anton-Paduraru, Dana-Teodora
Leca, Daniela
Miftode, Egidia Gabriela
Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic
title Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic
title_full Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic
title_fullStr Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic
title_full_unstemmed Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic
title_short Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic
title_sort mortality predictors in severe covid-19 patients from an east european tertiary center: a never-ending challenge for a no happy ending pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745635/
https://www.ncbi.nlm.nih.gov/pubmed/35011795
http://dx.doi.org/10.3390/jcm11010058
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