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The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions

Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the...

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Autores principales: Pallotti, Francesco, Bergamini, Christian, Lamperti, Costanza, Fato, Romana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745647/
https://www.ncbi.nlm.nih.gov/pubmed/35008564
http://dx.doi.org/10.3390/ijms23010128
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author Pallotti, Francesco
Bergamini, Christian
Lamperti, Costanza
Fato, Romana
author_facet Pallotti, Francesco
Bergamini, Christian
Lamperti, Costanza
Fato, Romana
author_sort Pallotti, Francesco
collection PubMed
description Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the toxic effect of free radicals, it is a component of LDL, it is involved in the aging process, and its deficiency is linked to several diseases. Recently, it has been proposed that coenzyme Q contributes to suppressing ferroptosis, a type of iron-dependent programmed cell death characterized by lipid peroxidation. In this review, we report the latest hypotheses and theories analyzing the multiple functions of coenzyme Q. The complete knowledge of the various cellular CoQ functions is essential to provide a rational basis for its possible therapeutic use, not only in diseases characterized by primary CoQ deficiency, but also in large number of diseases in which its secondary deficiency has been found.
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spelling pubmed-87456472022-01-11 The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions Pallotti, Francesco Bergamini, Christian Lamperti, Costanza Fato, Romana Int J Mol Sci Review Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the toxic effect of free radicals, it is a component of LDL, it is involved in the aging process, and its deficiency is linked to several diseases. Recently, it has been proposed that coenzyme Q contributes to suppressing ferroptosis, a type of iron-dependent programmed cell death characterized by lipid peroxidation. In this review, we report the latest hypotheses and theories analyzing the multiple functions of coenzyme Q. The complete knowledge of the various cellular CoQ functions is essential to provide a rational basis for its possible therapeutic use, not only in diseases characterized by primary CoQ deficiency, but also in large number of diseases in which its secondary deficiency has been found. MDPI 2021-12-23 /pmc/articles/PMC8745647/ /pubmed/35008564 http://dx.doi.org/10.3390/ijms23010128 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pallotti, Francesco
Bergamini, Christian
Lamperti, Costanza
Fato, Romana
The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
title The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
title_full The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
title_fullStr The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
title_full_unstemmed The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
title_short The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
title_sort roles of coenzyme q in disease: direct and indirect involvement in cellular functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745647/
https://www.ncbi.nlm.nih.gov/pubmed/35008564
http://dx.doi.org/10.3390/ijms23010128
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