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Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality

Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic lymphangiography (PAL) is a new technology for visualizing lymphatic vessels. It can depict lymphat...

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Autores principales: Suzuki, Yushi, Kajita, Hiroki, Watanabe, Shiho, Otaki, Marika, Okabe, Keisuke, Sakuma, Hisashi, Takatsume, Yoshifumi, Imanishi, Nobuaki, Aiso, Sadakazu, Kishi, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745664/
https://www.ncbi.nlm.nih.gov/pubmed/35011933
http://dx.doi.org/10.3390/jcm11010194
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author Suzuki, Yushi
Kajita, Hiroki
Watanabe, Shiho
Otaki, Marika
Okabe, Keisuke
Sakuma, Hisashi
Takatsume, Yoshifumi
Imanishi, Nobuaki
Aiso, Sadakazu
Kishi, Kazuo
author_facet Suzuki, Yushi
Kajita, Hiroki
Watanabe, Shiho
Otaki, Marika
Okabe, Keisuke
Sakuma, Hisashi
Takatsume, Yoshifumi
Imanishi, Nobuaki
Aiso, Sadakazu
Kishi, Kazuo
author_sort Suzuki, Yushi
collection PubMed
description Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic lymphangiography (PAL) is a new technology for visualizing lymphatic vessels. It can depict lymphatic vessels at high resolution; therefore, this study focused on how to apply PAL for lymphatic surgery. To visualize lymphatic vessels, indocyanine green was injected as a color agent. PAI-05 was used as the photoacoustic imaging device. Lymphatic vessels and veins were visualized at 797- and 835-nm wavelengths. First, it was confirmed whether the branching of the vasculature as depicted by the PAL was consistent with the actual branching of the vasculature as confirmed intraoperatively. Second, to use PAL images for surgical planning, preoperative photoacoustic images were superimposed onto the patient limb through augmented reality (AR) glasses (MOVERIO Smart Glass BT-30E). Lymphatics and venule markings drawn using AR glasses were consistent with the actual intraoperative images obtained during LVA. To anastomose multiple lymphatic vessels, a site with abundant venous branching was selected as the incision site; and selecting the incision site became easier. The anatomical morphology obtained by PAL matched the surgical field. AR-based marking could be very useful in future LVA.
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spelling pubmed-87456642022-01-11 Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality Suzuki, Yushi Kajita, Hiroki Watanabe, Shiho Otaki, Marika Okabe, Keisuke Sakuma, Hisashi Takatsume, Yoshifumi Imanishi, Nobuaki Aiso, Sadakazu Kishi, Kazuo J Clin Med Article Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic lymphangiography (PAL) is a new technology for visualizing lymphatic vessels. It can depict lymphatic vessels at high resolution; therefore, this study focused on how to apply PAL for lymphatic surgery. To visualize lymphatic vessels, indocyanine green was injected as a color agent. PAI-05 was used as the photoacoustic imaging device. Lymphatic vessels and veins were visualized at 797- and 835-nm wavelengths. First, it was confirmed whether the branching of the vasculature as depicted by the PAL was consistent with the actual branching of the vasculature as confirmed intraoperatively. Second, to use PAL images for surgical planning, preoperative photoacoustic images were superimposed onto the patient limb through augmented reality (AR) glasses (MOVERIO Smart Glass BT-30E). Lymphatics and venule markings drawn using AR glasses were consistent with the actual intraoperative images obtained during LVA. To anastomose multiple lymphatic vessels, a site with abundant venous branching was selected as the incision site; and selecting the incision site became easier. The anatomical morphology obtained by PAL matched the surgical field. AR-based marking could be very useful in future LVA. MDPI 2021-12-30 /pmc/articles/PMC8745664/ /pubmed/35011933 http://dx.doi.org/10.3390/jcm11010194 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suzuki, Yushi
Kajita, Hiroki
Watanabe, Shiho
Otaki, Marika
Okabe, Keisuke
Sakuma, Hisashi
Takatsume, Yoshifumi
Imanishi, Nobuaki
Aiso, Sadakazu
Kishi, Kazuo
Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
title Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
title_full Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
title_fullStr Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
title_full_unstemmed Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
title_short Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
title_sort surgical applications of lymphatic vessel visualization using photoacoustic imaging and augmented reality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745664/
https://www.ncbi.nlm.nih.gov/pubmed/35011933
http://dx.doi.org/10.3390/jcm11010194
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