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The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration
Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IG...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745665/ https://www.ncbi.nlm.nih.gov/pubmed/35008660 http://dx.doi.org/10.3390/ijms23010234 |
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author | Díaz del Moral, Sandra Benaouicha, Maha Muñoz-Chápuli, Ramón Carmona, Rita |
author_facet | Díaz del Moral, Sandra Benaouicha, Maha Muñoz-Chápuli, Ramón Carmona, Rita |
author_sort | Díaz del Moral, Sandra |
collection | PubMed |
description | Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the Igf1r and the insulin receptor (Insr) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart. |
format | Online Article Text |
id | pubmed-8745665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87456652022-01-11 The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration Díaz del Moral, Sandra Benaouicha, Maha Muñoz-Chápuli, Ramón Carmona, Rita Int J Mol Sci Review Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the Igf1r and the insulin receptor (Insr) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart. MDPI 2021-12-26 /pmc/articles/PMC8745665/ /pubmed/35008660 http://dx.doi.org/10.3390/ijms23010234 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Díaz del Moral, Sandra Benaouicha, Maha Muñoz-Chápuli, Ramón Carmona, Rita The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
title | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
title_full | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
title_fullStr | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
title_full_unstemmed | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
title_short | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration |
title_sort | insulin-like growth factor signalling pathway in cardiac development and regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745665/ https://www.ncbi.nlm.nih.gov/pubmed/35008660 http://dx.doi.org/10.3390/ijms23010234 |
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