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Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes

Cardiovascular diseases are the main cause of death worldwide, with coronary artery disease being the predominant underlying etiology. The most prevalent coronary lesions are represented by the atherosclerotic plaques, in more than 85% of cases, but there are several other non-atherosclerotic lesion...

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Autores principales: Spînu, Mihail, Onea, Laurenţiu Horea, Homorodean, Călin, Olinic, Maria, Ober, Mihai Claudiu, Olinic, Dan Mircea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745669/
https://www.ncbi.nlm.nih.gov/pubmed/35012006
http://dx.doi.org/10.3390/jcm11010265
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author Spînu, Mihail
Onea, Laurenţiu Horea
Homorodean, Călin
Olinic, Maria
Ober, Mihai Claudiu
Olinic, Dan Mircea
author_facet Spînu, Mihail
Onea, Laurenţiu Horea
Homorodean, Călin
Olinic, Maria
Ober, Mihai Claudiu
Olinic, Dan Mircea
author_sort Spînu, Mihail
collection PubMed
description Cardiovascular diseases are the main cause of death worldwide, with coronary artery disease being the predominant underlying etiology. The most prevalent coronary lesions are represented by the atherosclerotic plaques, in more than 85% of cases, but there are several other non-atherosclerotic lesions such as spontaneous coronary artery dissection and/or hematoma and spontaneous recanalization of coronary thrombus, which are less common, approximately 5% of cases, but with similar clinical manifestations as well as complications. There are insufficient data regarding the pathological mechanism, true prevalence and optimal treatment of these kind of coronary lesions. Optical coherence tomography (OCT) is an intracoronary imaging technique, developed in order to overcome the diagnostic limitations of a standard coronary angiography and has an extremely high resolution, similar to that of a usual histological evaluation of a biopsy sample, thus, OCT provides a histological-like information, but in a in vivo environment. The aim of this article is to review the current knowledge regarding non-atherosclerotic coronary lesions, with an emphasis on the importance of OCT for optimal identification, characterization of pathogenic mechanisms and optimal treatment selection.
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spelling pubmed-87456692022-01-11 Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes Spînu, Mihail Onea, Laurenţiu Horea Homorodean, Călin Olinic, Maria Ober, Mihai Claudiu Olinic, Dan Mircea J Clin Med Review Cardiovascular diseases are the main cause of death worldwide, with coronary artery disease being the predominant underlying etiology. The most prevalent coronary lesions are represented by the atherosclerotic plaques, in more than 85% of cases, but there are several other non-atherosclerotic lesions such as spontaneous coronary artery dissection and/or hematoma and spontaneous recanalization of coronary thrombus, which are less common, approximately 5% of cases, but with similar clinical manifestations as well as complications. There are insufficient data regarding the pathological mechanism, true prevalence and optimal treatment of these kind of coronary lesions. Optical coherence tomography (OCT) is an intracoronary imaging technique, developed in order to overcome the diagnostic limitations of a standard coronary angiography and has an extremely high resolution, similar to that of a usual histological evaluation of a biopsy sample, thus, OCT provides a histological-like information, but in a in vivo environment. The aim of this article is to review the current knowledge regarding non-atherosclerotic coronary lesions, with an emphasis on the importance of OCT for optimal identification, characterization of pathogenic mechanisms and optimal treatment selection. MDPI 2022-01-05 /pmc/articles/PMC8745669/ /pubmed/35012006 http://dx.doi.org/10.3390/jcm11010265 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Spînu, Mihail
Onea, Laurenţiu Horea
Homorodean, Călin
Olinic, Maria
Ober, Mihai Claudiu
Olinic, Dan Mircea
Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes
title Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes
title_full Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes
title_fullStr Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes
title_full_unstemmed Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes
title_short Optical Coherence Tomography—OCT for Characterization of Non-Atherosclerotic Coronary Lesions in Acute Coronary Syndromes
title_sort optical coherence tomography—oct for characterization of non-atherosclerotic coronary lesions in acute coronary syndromes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745669/
https://www.ncbi.nlm.nih.gov/pubmed/35012006
http://dx.doi.org/10.3390/jcm11010265
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