Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors

(1R,5S)-1-Hydroxy-3,6-dioxa-bicyclo[3.2.1]octan-2-one, available by an efficient catalytic pyrolysis of cellulose, has been applied as a chiral building block in the synthesis of seven new nucleoside analogues, with structural modifications on the nucleobase moiety and on the carboxyl- derived unit....

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Detalles Bibliográficos
Autores principales: Defant, Andrea, Dosi, Federico, Innocenti, Nicole, Mancini, Ines
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745730/
https://www.ncbi.nlm.nih.gov/pubmed/35008944
http://dx.doi.org/10.3390/ijms23010518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745730/
https://www.ncbi.nlm.nih.gov/pubmed/35008944
http://dx.doi.org/10.3390/ijms23010518

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