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Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease

Circulating osteoprotegerin (OPG) is a biomarker for cardiovascular complications that are closely related to chronic kidney disease (CKD). To investigate the association between circulating OPG level with long-term visit-to-visit blood pressure variability (BPV) in patients with pre-dialysis CKD, a...

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Autores principales: Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Oh, Kook-Hwan, Lee, Joongyub, Oh, Yun Kyu, Jung, Ji Yong, Choi, Kyu Hun, Ma, Seong Kwon, Bae, Eun Hui, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745733/
https://www.ncbi.nlm.nih.gov/pubmed/35011919
http://dx.doi.org/10.3390/jcm11010178
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author Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Oh, Kook-Hwan
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Choi, Kyu Hun
Ma, Seong Kwon
Bae, Eun Hui
Kim, Soo Wan
author_facet Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Oh, Kook-Hwan
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Choi, Kyu Hun
Ma, Seong Kwon
Bae, Eun Hui
Kim, Soo Wan
author_sort Suh, Sang Heon
collection PubMed
description Circulating osteoprotegerin (OPG) is a biomarker for cardiovascular complications that are closely related to chronic kidney disease (CKD). To investigate the association between circulating OPG level with long-term visit-to-visit blood pressure variability (BPV) in patients with pre-dialysis CKD, a total of 1855 subjects with CKD from stage 1 to pre-dialysis stage 5 from a prospective cohort were analyzed. Long-term visit-to-visit BPV was determined by average real variability (ARV), standard deviation (SD), and coefficient of variation (CoV) of systolic and diastolic blood pressure (SBP and DBP). ARV of SBP (Adjusted β coefficient 0.143, 95% confidence interval 0.021 to 0.264) was significantly associated with serum OPG level. Although SD and CoV of SBP were not significantly associated with serum OPG level in multivariate linear regression analyses, restricted cubic spline visualized the linear correlation of serum OPG level with all of ARV, SD, and CoV. The association between serum OPG level and DBP variability was not significant. Subgroup analyses revealed that the association of serum OPG with BPV is more prominent in the subjects with Charlson comorbidity index ≤3 and in the subjects without history of diabetes mellitus. In conclusion, circulating OPG level is potentially associated with long-term visit-to-visit BPV in patients with pre-dialysis CKD.
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spelling pubmed-87457332022-01-11 Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Oh, Kook-Hwan Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Choi, Kyu Hun Ma, Seong Kwon Bae, Eun Hui Kim, Soo Wan J Clin Med Article Circulating osteoprotegerin (OPG) is a biomarker for cardiovascular complications that are closely related to chronic kidney disease (CKD). To investigate the association between circulating OPG level with long-term visit-to-visit blood pressure variability (BPV) in patients with pre-dialysis CKD, a total of 1855 subjects with CKD from stage 1 to pre-dialysis stage 5 from a prospective cohort were analyzed. Long-term visit-to-visit BPV was determined by average real variability (ARV), standard deviation (SD), and coefficient of variation (CoV) of systolic and diastolic blood pressure (SBP and DBP). ARV of SBP (Adjusted β coefficient 0.143, 95% confidence interval 0.021 to 0.264) was significantly associated with serum OPG level. Although SD and CoV of SBP were not significantly associated with serum OPG level in multivariate linear regression analyses, restricted cubic spline visualized the linear correlation of serum OPG level with all of ARV, SD, and CoV. The association between serum OPG level and DBP variability was not significant. Subgroup analyses revealed that the association of serum OPG with BPV is more prominent in the subjects with Charlson comorbidity index ≤3 and in the subjects without history of diabetes mellitus. In conclusion, circulating OPG level is potentially associated with long-term visit-to-visit BPV in patients with pre-dialysis CKD. MDPI 2021-12-29 /pmc/articles/PMC8745733/ /pubmed/35011919 http://dx.doi.org/10.3390/jcm11010178 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Oh, Kook-Hwan
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Choi, Kyu Hun
Ma, Seong Kwon
Bae, Eun Hui
Kim, Soo Wan
Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease
title Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease
title_full Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease
title_fullStr Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease
title_full_unstemmed Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease
title_short Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease
title_sort association of circulating osteoprotegerin level with blood pressure variability in patients with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745733/
https://www.ncbi.nlm.nih.gov/pubmed/35011919
http://dx.doi.org/10.3390/jcm11010178
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