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Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine
Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin pigments is a protective response against the damaging effects of UV radiation in skin. However, pheomelanin, like ot...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745751/ https://www.ncbi.nlm.nih.gov/pubmed/35008693 http://dx.doi.org/10.3390/ijms23010267 |
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author | Mariano, Alessia Bigioni, Irene Scotto d’Abusco, Anna Baseggio Conrado, Alessia Maina, Simonetta Francioso, Antonio Mosca, Luciana Fontana, Mario |
author_facet | Mariano, Alessia Bigioni, Irene Scotto d’Abusco, Anna Baseggio Conrado, Alessia Maina, Simonetta Francioso, Antonio Mosca, Luciana Fontana, Mario |
author_sort | Mariano, Alessia |
collection | PubMed |
description | Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin pigments is a protective response against the damaging effects of UV radiation in skin. However, pheomelanin, like other photosensitizing substances, can trigger, following exposure to UV radiation, photochemical reactions capable of modifying and damaging cellular components. The photoproperties of this natural pigment have been studied by analyzing pheomelanin effect on oxidation/nitration of tyrosine induced by UVB radiation at different pH values and in presence of iron ions. Photoproperties of pheomelanin can be modulated by various experimental conditions, ranging from the photoprotection to the triggering of potentially damaging photochemical reactions. The study of the photomodification of l-Tyrosine in the presence of the natural pigment pheomelanin has a special relevance, since this tyrosine oxidation/nitration pathway can potentially occur in vivo in tissues exposed to sunlight and play a role in the mechanisms of tissue damage induced by UV radiation. |
format | Online Article Text |
id | pubmed-8745751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87457512022-01-11 Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine Mariano, Alessia Bigioni, Irene Scotto d’Abusco, Anna Baseggio Conrado, Alessia Maina, Simonetta Francioso, Antonio Mosca, Luciana Fontana, Mario Int J Mol Sci Article Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin pigments is a protective response against the damaging effects of UV radiation in skin. However, pheomelanin, like other photosensitizing substances, can trigger, following exposure to UV radiation, photochemical reactions capable of modifying and damaging cellular components. The photoproperties of this natural pigment have been studied by analyzing pheomelanin effect on oxidation/nitration of tyrosine induced by UVB radiation at different pH values and in presence of iron ions. Photoproperties of pheomelanin can be modulated by various experimental conditions, ranging from the photoprotection to the triggering of potentially damaging photochemical reactions. The study of the photomodification of l-Tyrosine in the presence of the natural pigment pheomelanin has a special relevance, since this tyrosine oxidation/nitration pathway can potentially occur in vivo in tissues exposed to sunlight and play a role in the mechanisms of tissue damage induced by UV radiation. MDPI 2021-12-27 /pmc/articles/PMC8745751/ /pubmed/35008693 http://dx.doi.org/10.3390/ijms23010267 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mariano, Alessia Bigioni, Irene Scotto d’Abusco, Anna Baseggio Conrado, Alessia Maina, Simonetta Francioso, Antonio Mosca, Luciana Fontana, Mario Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine |
title | Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine |
title_full | Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine |
title_fullStr | Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine |
title_full_unstemmed | Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine |
title_short | Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine |
title_sort | pheomelanin effect on uvb radiation-induced oxidation/nitration of l-tyrosine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745751/ https://www.ncbi.nlm.nih.gov/pubmed/35008693 http://dx.doi.org/10.3390/ijms23010267 |
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