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Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease

The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imag...

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Autores principales: Alé-Chilet, Aníbal, Bernal-Morales, Carolina, Barraso, Marina, Hernández, Teresa, Oliva, Cristian, Vinagre, Irene, Ortega, Emilio, Figueras-Roca, Marc, Sala-Puigdollers, Anna, Esquinas, Cristina, Gimenez, Marga, Esmatjes, Enric, Adán, Alfredo, Zarranz-Ventura, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745787/
https://www.ncbi.nlm.nih.gov/pubmed/35011940
http://dx.doi.org/10.3390/jcm11010197
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author Alé-Chilet, Aníbal
Bernal-Morales, Carolina
Barraso, Marina
Hernández, Teresa
Oliva, Cristian
Vinagre, Irene
Ortega, Emilio
Figueras-Roca, Marc
Sala-Puigdollers, Anna
Esquinas, Cristina
Gimenez, Marga
Esmatjes, Enric
Adán, Alfredo
Zarranz-Ventura, Javier
author_facet Alé-Chilet, Aníbal
Bernal-Morales, Carolina
Barraso, Marina
Hernández, Teresa
Oliva, Cristian
Vinagre, Irene
Ortega, Emilio
Figueras-Roca, Marc
Sala-Puigdollers, Anna
Esquinas, Cristina
Gimenez, Marga
Esmatjes, Enric
Adán, Alfredo
Zarranz-Ventura, Javier
author_sort Alé-Chilet, Aníbal
collection PubMed
description The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imaging tests and bloods, was performed. OCTA parameters included vessel density (VD), perfusion density (PD), foveal avascular zone area (FAZa), perimeter (FAZp) and circularity (FAZc) in the superficial vascular plexus, and DKD categories were defined according to glomerular filtration rate (GFR), albumin-creatinine ratio (ACR) and KDIGO prognosis risk classifications. A total of 425 individuals (1 eye/1 patient) were included. Reduced VD and FAZc were associated with greater categories of GFR (p = 0.002, p = 0.04), ACR (p = 0.003, p = 0.005) and KDIGO risk prognosis classifications (p = 0.002, p = 0.005). FAZc was significantly reduced in greater KDIGO prognosis risk categories (low risk vs. moderate risk, 0.65 ± 0.09 vs. 0.60 ± 0.07, p < 0.05). VD and FAZc presented the best diagnostic performance in ROCs. In conclusion, OCTA parameters, such as VD and FAZc, are able to detect different GFR, ACR, and KDIGO categories in T1DM patients and controls in a non-invasive, objective quantitative way. FAZc is able to discriminate within T1DM patients those with greater DKD categories and greater risk of DKD progression.
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spelling pubmed-87457872022-01-11 Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease Alé-Chilet, Aníbal Bernal-Morales, Carolina Barraso, Marina Hernández, Teresa Oliva, Cristian Vinagre, Irene Ortega, Emilio Figueras-Roca, Marc Sala-Puigdollers, Anna Esquinas, Cristina Gimenez, Marga Esmatjes, Enric Adán, Alfredo Zarranz-Ventura, Javier J Clin Med Article The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imaging tests and bloods, was performed. OCTA parameters included vessel density (VD), perfusion density (PD), foveal avascular zone area (FAZa), perimeter (FAZp) and circularity (FAZc) in the superficial vascular plexus, and DKD categories were defined according to glomerular filtration rate (GFR), albumin-creatinine ratio (ACR) and KDIGO prognosis risk classifications. A total of 425 individuals (1 eye/1 patient) were included. Reduced VD and FAZc were associated with greater categories of GFR (p = 0.002, p = 0.04), ACR (p = 0.003, p = 0.005) and KDIGO risk prognosis classifications (p = 0.002, p = 0.005). FAZc was significantly reduced in greater KDIGO prognosis risk categories (low risk vs. moderate risk, 0.65 ± 0.09 vs. 0.60 ± 0.07, p < 0.05). VD and FAZc presented the best diagnostic performance in ROCs. In conclusion, OCTA parameters, such as VD and FAZc, are able to detect different GFR, ACR, and KDIGO categories in T1DM patients and controls in a non-invasive, objective quantitative way. FAZc is able to discriminate within T1DM patients those with greater DKD categories and greater risk of DKD progression. MDPI 2021-12-30 /pmc/articles/PMC8745787/ /pubmed/35011940 http://dx.doi.org/10.3390/jcm11010197 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alé-Chilet, Aníbal
Bernal-Morales, Carolina
Barraso, Marina
Hernández, Teresa
Oliva, Cristian
Vinagre, Irene
Ortega, Emilio
Figueras-Roca, Marc
Sala-Puigdollers, Anna
Esquinas, Cristina
Gimenez, Marga
Esmatjes, Enric
Adán, Alfredo
Zarranz-Ventura, Javier
Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease
title Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease
title_full Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease
title_fullStr Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease
title_full_unstemmed Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease
title_short Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease
title_sort optical coherence tomography angiography in type 1 diabetes mellitus—report 2: diabetic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745787/
https://www.ncbi.nlm.nih.gov/pubmed/35011940
http://dx.doi.org/10.3390/jcm11010197
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