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Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research
Research on the cellular response to electrical stimulation (ES) and its mechanisms focusing on potential clinic applications has been quietly intensified recently. However, the unconventional nature of this methodology has fertilized a great variety of techniques that make the interpretation and co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746014/ https://www.ncbi.nlm.nih.gov/pubmed/35009311 http://dx.doi.org/10.3390/ma15010165 |
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author | Meng, Shiyun Rouabhia, Mahmoud Zhang, Ze |
author_facet | Meng, Shiyun Rouabhia, Mahmoud Zhang, Ze |
author_sort | Meng, Shiyun |
collection | PubMed |
description | Research on the cellular response to electrical stimulation (ES) and its mechanisms focusing on potential clinic applications has been quietly intensified recently. However, the unconventional nature of this methodology has fertilized a great variety of techniques that make the interpretation and comparison of experimental outcomes complicated. This work reviews more than a hundred publications identified mostly from Medline, categorizes the techniques, and comments on their merits and weaknesses. Electrode-based ES, conductive substrate-mediated ES, and noninvasive stimulation are the three principal categories used in biomedical research and clinic. ES has been found to enhance cell proliferation, growth, migration, and stem cell differentiation, showing an important potential in manipulating cellular activities in both normal and pathological conditions. However, inappropriate parameters or setup can have negative effects. The complexity of the delivered electric signals depends on how they are generated and in what form. It is also difficult to equate one set of parameters with another. Mechanistic studies are rare and badly needed. Even so, ES in combination with advanced materials and nanotechnology is developing a strong footing in biomedical research and regenerative medicine. |
format | Online Article Text |
id | pubmed-8746014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87460142022-01-11 Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research Meng, Shiyun Rouabhia, Mahmoud Zhang, Ze Materials (Basel) Review Research on the cellular response to electrical stimulation (ES) and its mechanisms focusing on potential clinic applications has been quietly intensified recently. However, the unconventional nature of this methodology has fertilized a great variety of techniques that make the interpretation and comparison of experimental outcomes complicated. This work reviews more than a hundred publications identified mostly from Medline, categorizes the techniques, and comments on their merits and weaknesses. Electrode-based ES, conductive substrate-mediated ES, and noninvasive stimulation are the three principal categories used in biomedical research and clinic. ES has been found to enhance cell proliferation, growth, migration, and stem cell differentiation, showing an important potential in manipulating cellular activities in both normal and pathological conditions. However, inappropriate parameters or setup can have negative effects. The complexity of the delivered electric signals depends on how they are generated and in what form. It is also difficult to equate one set of parameters with another. Mechanistic studies are rare and badly needed. Even so, ES in combination with advanced materials and nanotechnology is developing a strong footing in biomedical research and regenerative medicine. MDPI 2021-12-27 /pmc/articles/PMC8746014/ /pubmed/35009311 http://dx.doi.org/10.3390/ma15010165 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Meng, Shiyun Rouabhia, Mahmoud Zhang, Ze Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research |
title | Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research |
title_full | Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research |
title_fullStr | Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research |
title_full_unstemmed | Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research |
title_short | Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research |
title_sort | electrical stimulation and cellular behaviors in electric field in biomedical research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746014/ https://www.ncbi.nlm.nih.gov/pubmed/35009311 http://dx.doi.org/10.3390/ma15010165 |
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