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Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease

(1) Background: This observational study aimed to verify the association between serum potassium levels and hospitalization days in patients with chronic kidney disease in a follow up of nine months. (2) Methods: Patients with chronic kidney disease were divided into group A (180 patients, potassium...

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Autores principales: Calabrese, Vincenzo, Cernaro, Valeria, Battaglia, Valeria, Gembillo, Guido, Longhitano, Elisa, Siligato, Rossella, Sposito, Giovanna, Ferlazzo, Guido, Santoro, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746076/
https://www.ncbi.nlm.nih.gov/pubmed/35011985
http://dx.doi.org/10.3390/jcm11010244
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author Calabrese, Vincenzo
Cernaro, Valeria
Battaglia, Valeria
Gembillo, Guido
Longhitano, Elisa
Siligato, Rossella
Sposito, Giovanna
Ferlazzo, Guido
Santoro, Domenico
author_facet Calabrese, Vincenzo
Cernaro, Valeria
Battaglia, Valeria
Gembillo, Guido
Longhitano, Elisa
Siligato, Rossella
Sposito, Giovanna
Ferlazzo, Guido
Santoro, Domenico
author_sort Calabrese, Vincenzo
collection PubMed
description (1) Background: This observational study aimed to verify the association between serum potassium levels and hospitalization days in patients with chronic kidney disease in a follow up of nine months. (2) Methods: Patients with chronic kidney disease were divided into group A (180 patients, potassium ≤ 5.1 mEq/L) and B (90 patients, potassium > 5.1 mEq/L). Student’s t-test, Mann–Whitney test, Pearson’s Chi-Square test, Pearson/Spearman’s correlation test and linear regression test were performed in the entire sample and in stage-G4/5 subsample. (3) Results: Groups A and B differed for estimated glomerular filtration rate (eGFR) (34.89 (IQR, 16.24–57.98) vs. 19.8 (IQR, 10.50–32.50) mL/min/1.73 m(2); p < 0.0001), hemoglobin (11.64 ± 2.20 vs. 10.97 ± 2.19 g/dL, p = 0.048), sum of hospitalization days (8 (IQR, 6–10) vs. 11 (IQR, 7–15) days; p < 0.0001) and use of angiotensin II receptor blockers (40.2% vs. 53.3%; p = 0.010). Considering patients with eGFR 6–30 mL/min/1.73 m(2), differences in the sum of hospitalization days were confirmed. Multivariable regression analysis showed that hyperkalemia is an independent risk factor of increased hospital length. In stage G4-G5, regression analysis showed that hyperkalemia is the only independent risk factor (β = 2.93, 95% confidence interval, 0.077–5.794, p = 0.044). (4) Conclusions: We observed significantly greater odds of increased length of hospital stay among patients with higher potassium, mostly in stages G4–G5 chronic kidney disease.
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spelling pubmed-87460762022-01-11 Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease Calabrese, Vincenzo Cernaro, Valeria Battaglia, Valeria Gembillo, Guido Longhitano, Elisa Siligato, Rossella Sposito, Giovanna Ferlazzo, Guido Santoro, Domenico J Clin Med Article (1) Background: This observational study aimed to verify the association between serum potassium levels and hospitalization days in patients with chronic kidney disease in a follow up of nine months. (2) Methods: Patients with chronic kidney disease were divided into group A (180 patients, potassium ≤ 5.1 mEq/L) and B (90 patients, potassium > 5.1 mEq/L). Student’s t-test, Mann–Whitney test, Pearson’s Chi-Square test, Pearson/Spearman’s correlation test and linear regression test were performed in the entire sample and in stage-G4/5 subsample. (3) Results: Groups A and B differed for estimated glomerular filtration rate (eGFR) (34.89 (IQR, 16.24–57.98) vs. 19.8 (IQR, 10.50–32.50) mL/min/1.73 m(2); p < 0.0001), hemoglobin (11.64 ± 2.20 vs. 10.97 ± 2.19 g/dL, p = 0.048), sum of hospitalization days (8 (IQR, 6–10) vs. 11 (IQR, 7–15) days; p < 0.0001) and use of angiotensin II receptor blockers (40.2% vs. 53.3%; p = 0.010). Considering patients with eGFR 6–30 mL/min/1.73 m(2), differences in the sum of hospitalization days were confirmed. Multivariable regression analysis showed that hyperkalemia is an independent risk factor of increased hospital length. In stage G4-G5, regression analysis showed that hyperkalemia is the only independent risk factor (β = 2.93, 95% confidence interval, 0.077–5.794, p = 0.044). (4) Conclusions: We observed significantly greater odds of increased length of hospital stay among patients with higher potassium, mostly in stages G4–G5 chronic kidney disease. MDPI 2022-01-04 /pmc/articles/PMC8746076/ /pubmed/35011985 http://dx.doi.org/10.3390/jcm11010244 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calabrese, Vincenzo
Cernaro, Valeria
Battaglia, Valeria
Gembillo, Guido
Longhitano, Elisa
Siligato, Rossella
Sposito, Giovanna
Ferlazzo, Guido
Santoro, Domenico
Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease
title Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease
title_full Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease
title_fullStr Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease
title_full_unstemmed Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease
title_short Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease
title_sort correlation between hyperkalemia and the duration of several hospitalizations in patients with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746076/
https://www.ncbi.nlm.nih.gov/pubmed/35011985
http://dx.doi.org/10.3390/jcm11010244
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