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Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?

Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks...

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Autores principales: Durazzo, Marilena, Ferro, Arianna, Brascugli, Isabella, Mattivi, Simone, Fagoonee, Sharmila, Pellicano, Rinaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746138/
https://www.ncbi.nlm.nih.gov/pubmed/35011999
http://dx.doi.org/10.3390/jcm11010258
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author Durazzo, Marilena
Ferro, Arianna
Brascugli, Isabella
Mattivi, Simone
Fagoonee, Sharmila
Pellicano, Rinaldo
author_facet Durazzo, Marilena
Ferro, Arianna
Brascugli, Isabella
Mattivi, Simone
Fagoonee, Sharmila
Pellicano, Rinaldo
author_sort Durazzo, Marilena
collection PubMed
description Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis.
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spelling pubmed-87461382022-01-11 Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? Durazzo, Marilena Ferro, Arianna Brascugli, Isabella Mattivi, Simone Fagoonee, Sharmila Pellicano, Rinaldo J Clin Med Review Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis. MDPI 2022-01-04 /pmc/articles/PMC8746138/ /pubmed/35011999 http://dx.doi.org/10.3390/jcm11010258 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Durazzo, Marilena
Ferro, Arianna
Brascugli, Isabella
Mattivi, Simone
Fagoonee, Sharmila
Pellicano, Rinaldo
Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
title Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
title_full Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
title_fullStr Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
title_full_unstemmed Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
title_short Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
title_sort extra-intestinal manifestations of celiac disease: what should we know in 2022?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746138/
https://www.ncbi.nlm.nih.gov/pubmed/35011999
http://dx.doi.org/10.3390/jcm11010258
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