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ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome

Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associa...

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Autores principales: Martin-Loeches, Ignacio, Motos, Anna, Menéndez, Rosario, Gabarrús, Albert, González, Jessica, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Ferrer, Ricard, Riera, Jordi, Lorente, José Ángel, Peñuelas, Óscar, Bermejo-Martin, Jesús F., de Gonzalo-Calvo, David, Rodríguez, Alejandro, Barbé, Ferran, Aguilera, Luciano, Amaya-Villar, Rosario, Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marín-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, Lopez Messa, Juan, Albaiceta, Guillermo M., Novo, Mariana Andrea, Peñasco, Yhivian, Ricart, Pilar, Urrelo-Cerrón, Luis, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Tamayo Lomas, Luis, Vidal, Pablo, Torres, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746263/
https://www.ncbi.nlm.nih.gov/pubmed/35011967
http://dx.doi.org/10.3390/jcm11010224
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author Martin-Loeches, Ignacio
Motos, Anna
Menéndez, Rosario
Gabarrús, Albert
González, Jessica
Fernández-Barat, Laia
Ceccato, Adrián
Pérez-Arnal, Raquel
García-Gasulla, Dario
Ferrer, Ricard
Riera, Jordi
Lorente, José Ángel
Peñuelas, Óscar
Bermejo-Martin, Jesús F.
de Gonzalo-Calvo, David
Rodríguez, Alejandro
Barbé, Ferran
Aguilera, Luciano
Amaya-Villar, Rosario
Barberà, Carme
Barberán, José
Blandino Ortiz, Aaron
Bustamante-Munguira, Elena
Caballero, Jesús
Carbajales, Cristina
Carbonell, Nieves
Catalán-González, Mercedes
Galbán, Cristóbal
Gumucio-Sanguino, Víctor D.
de la Torre, Maria del Carmen
Díaz, Emili
Gallego, Elena
García Garmendia, José Luis
Garnacho-Montero, José
Gómez, José M.
Jorge García, Ruth Noemí
Loza-Vázquez, Ana
Marín-Corral, Judith
Martínez de la Gándara, Amalia
Martínez Varela, Ignacio
Lopez Messa, Juan
Albaiceta, Guillermo M.
Novo, Mariana Andrea
Peñasco, Yhivian
Ricart, Pilar
Urrelo-Cerrón, Luis
Sánchez-Miralles, Angel
Sancho Chinesta, Susana
Socias, Lorenzo
Solé-Violan, Jordi
Tamayo Lomas, Luis
Vidal, Pablo
Torres, Antoni
author_facet Martin-Loeches, Ignacio
Motos, Anna
Menéndez, Rosario
Gabarrús, Albert
González, Jessica
Fernández-Barat, Laia
Ceccato, Adrián
Pérez-Arnal, Raquel
García-Gasulla, Dario
Ferrer, Ricard
Riera, Jordi
Lorente, José Ángel
Peñuelas, Óscar
Bermejo-Martin, Jesús F.
de Gonzalo-Calvo, David
Rodríguez, Alejandro
Barbé, Ferran
Aguilera, Luciano
Amaya-Villar, Rosario
Barberà, Carme
Barberán, José
Blandino Ortiz, Aaron
Bustamante-Munguira, Elena
Caballero, Jesús
Carbajales, Cristina
Carbonell, Nieves
Catalán-González, Mercedes
Galbán, Cristóbal
Gumucio-Sanguino, Víctor D.
de la Torre, Maria del Carmen
Díaz, Emili
Gallego, Elena
García Garmendia, José Luis
Garnacho-Montero, José
Gómez, José M.
Jorge García, Ruth Noemí
Loza-Vázquez, Ana
Marín-Corral, Judith
Martínez de la Gándara, Amalia
Martínez Varela, Ignacio
Lopez Messa, Juan
Albaiceta, Guillermo M.
Novo, Mariana Andrea
Peñasco, Yhivian
Ricart, Pilar
Urrelo-Cerrón, Luis
Sánchez-Miralles, Angel
Sancho Chinesta, Susana
Socias, Lorenzo
Solé-Violan, Jordi
Tamayo Lomas, Luis
Vidal, Pablo
Torres, Antoni
author_sort Martin-Loeches, Ignacio
collection PubMed
description Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19.
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spelling pubmed-87462632022-01-11 ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome Martin-Loeches, Ignacio Motos, Anna Menéndez, Rosario Gabarrús, Albert González, Jessica Fernández-Barat, Laia Ceccato, Adrián Pérez-Arnal, Raquel García-Gasulla, Dario Ferrer, Ricard Riera, Jordi Lorente, José Ángel Peñuelas, Óscar Bermejo-Martin, Jesús F. de Gonzalo-Calvo, David Rodríguez, Alejandro Barbé, Ferran Aguilera, Luciano Amaya-Villar, Rosario Barberà, Carme Barberán, José Blandino Ortiz, Aaron Bustamante-Munguira, Elena Caballero, Jesús Carbajales, Cristina Carbonell, Nieves Catalán-González, Mercedes Galbán, Cristóbal Gumucio-Sanguino, Víctor D. de la Torre, Maria del Carmen Díaz, Emili Gallego, Elena García Garmendia, José Luis Garnacho-Montero, José Gómez, José M. Jorge García, Ruth Noemí Loza-Vázquez, Ana Marín-Corral, Judith Martínez de la Gándara, Amalia Martínez Varela, Ignacio Lopez Messa, Juan Albaiceta, Guillermo M. Novo, Mariana Andrea Peñasco, Yhivian Ricart, Pilar Urrelo-Cerrón, Luis Sánchez-Miralles, Angel Sancho Chinesta, Susana Socias, Lorenzo Solé-Violan, Jordi Tamayo Lomas, Luis Vidal, Pablo Torres, Antoni J Clin Med Article Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19. MDPI 2021-12-31 /pmc/articles/PMC8746263/ /pubmed/35011967 http://dx.doi.org/10.3390/jcm11010224 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martin-Loeches, Ignacio
Motos, Anna
Menéndez, Rosario
Gabarrús, Albert
González, Jessica
Fernández-Barat, Laia
Ceccato, Adrián
Pérez-Arnal, Raquel
García-Gasulla, Dario
Ferrer, Ricard
Riera, Jordi
Lorente, José Ángel
Peñuelas, Óscar
Bermejo-Martin, Jesús F.
de Gonzalo-Calvo, David
Rodríguez, Alejandro
Barbé, Ferran
Aguilera, Luciano
Amaya-Villar, Rosario
Barberà, Carme
Barberán, José
Blandino Ortiz, Aaron
Bustamante-Munguira, Elena
Caballero, Jesús
Carbajales, Cristina
Carbonell, Nieves
Catalán-González, Mercedes
Galbán, Cristóbal
Gumucio-Sanguino, Víctor D.
de la Torre, Maria del Carmen
Díaz, Emili
Gallego, Elena
García Garmendia, José Luis
Garnacho-Montero, José
Gómez, José M.
Jorge García, Ruth Noemí
Loza-Vázquez, Ana
Marín-Corral, Judith
Martínez de la Gándara, Amalia
Martínez Varela, Ignacio
Lopez Messa, Juan
Albaiceta, Guillermo M.
Novo, Mariana Andrea
Peñasco, Yhivian
Ricart, Pilar
Urrelo-Cerrón, Luis
Sánchez-Miralles, Angel
Sancho Chinesta, Susana
Socias, Lorenzo
Solé-Violan, Jordi
Tamayo Lomas, Luis
Vidal, Pablo
Torres, Antoni
ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
title ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
title_full ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
title_fullStr ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
title_full_unstemmed ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
title_short ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
title_sort icu-acquired pneumonia is associated with poor health post-covid-19 syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746263/
https://www.ncbi.nlm.nih.gov/pubmed/35011967
http://dx.doi.org/10.3390/jcm11010224
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