Cargando…

Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand

The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antivira...

Descripción completa

Detalles Bibliográficos
Autores principales: Gutiérrez, Daniela, Benavides, Almendra, Valenzuela, Beatriz, Mascayano, Carolina, Aldabaldetrecu, Maialen, Olguín, Angel, Guerrero, Juan, Modak, Brenda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746282/
https://www.ncbi.nlm.nih.gov/pubmed/35011264
http://dx.doi.org/10.3390/molecules27010032
_version_ 1784630547405864960
author Gutiérrez, Daniela
Benavides, Almendra
Valenzuela, Beatriz
Mascayano, Carolina
Aldabaldetrecu, Maialen
Olguín, Angel
Guerrero, Juan
Modak, Brenda
author_facet Gutiérrez, Daniela
Benavides, Almendra
Valenzuela, Beatriz
Mascayano, Carolina
Aldabaldetrecu, Maialen
Olguín, Angel
Guerrero, Juan
Modak, Brenda
author_sort Gutiérrez, Daniela
collection PubMed
description The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antiviral effect of [Cu(NN(1))(2)](ClO(4)) Cu(I) complex, synthesized in our laboratory, where the NN(1) ligand is a synthetic derivate of the natural compound coumarin. This complex demonstrated antiviral activity against IPNV at 5.0 and 15.0 µg/mL causing a decrease viral load 99.0% and 99.5%, respectively. The Molecular Docking studies carried out showed that the copper complex would interact with the VP2 protein, specifically in the S domain, altering the process of entry of the virus into the host cell.
format Online
Article
Text
id pubmed-8746282
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87462822022-01-11 Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand Gutiérrez, Daniela Benavides, Almendra Valenzuela, Beatriz Mascayano, Carolina Aldabaldetrecu, Maialen Olguín, Angel Guerrero, Juan Modak, Brenda Molecules Article The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antiviral effect of [Cu(NN(1))(2)](ClO(4)) Cu(I) complex, synthesized in our laboratory, where the NN(1) ligand is a synthetic derivate of the natural compound coumarin. This complex demonstrated antiviral activity against IPNV at 5.0 and 15.0 µg/mL causing a decrease viral load 99.0% and 99.5%, respectively. The Molecular Docking studies carried out showed that the copper complex would interact with the VP2 protein, specifically in the S domain, altering the process of entry of the virus into the host cell. MDPI 2021-12-22 /pmc/articles/PMC8746282/ /pubmed/35011264 http://dx.doi.org/10.3390/molecules27010032 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gutiérrez, Daniela
Benavides, Almendra
Valenzuela, Beatriz
Mascayano, Carolina
Aldabaldetrecu, Maialen
Olguín, Angel
Guerrero, Juan
Modak, Brenda
Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand
title Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand
title_full Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand
title_fullStr Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand
title_full_unstemmed Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand
title_short Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand
title_sort evaluation of the antiviral activity against infectious pancreatic necrosis virus (ipnv) of a copper (i) homoleptic complex with a coumarin as ligand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746282/
https://www.ncbi.nlm.nih.gov/pubmed/35011264
http://dx.doi.org/10.3390/molecules27010032
work_keys_str_mv AT gutierrezdaniela evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT benavidesalmendra evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT valenzuelabeatriz evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT mascayanocarolina evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT aldabaldetrecumaialen evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT olguinangel evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT guerrerojuan evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand
AT modakbrenda evaluationoftheantiviralactivityagainstinfectiouspancreaticnecrosisvirusipnvofacopperihomolepticcomplexwithacoumarinasligand