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Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes

Moringa oleifera (MO) is a multipurpose plant with a high polyphenol content, which is being increasingly consumed to lessen the risk of chronic metabolic diseases such as Type 2 diabetes; however, scientific evidence from clinical trials is scarce. A double-blind, randomized, placebo-controlled, pa...

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Autores principales: Gómez-Martínez, Sonia, Díaz-Prieto, Ligia E., Castro, Iván Vicente, Jurado, César, Iturmendi, Nerea, Martín-Ridaura, Maria Carmen, Calle, Nuria, Dueñas, María, Picón, María J., Marcos, Ascensión, Nova, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746299/
https://www.ncbi.nlm.nih.gov/pubmed/35010932
http://dx.doi.org/10.3390/nu14010057
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author Gómez-Martínez, Sonia
Díaz-Prieto, Ligia E.
Castro, Iván Vicente
Jurado, César
Iturmendi, Nerea
Martín-Ridaura, Maria Carmen
Calle, Nuria
Dueñas, María
Picón, María J.
Marcos, Ascensión
Nova, Esther
author_facet Gómez-Martínez, Sonia
Díaz-Prieto, Ligia E.
Castro, Iván Vicente
Jurado, César
Iturmendi, Nerea
Martín-Ridaura, Maria Carmen
Calle, Nuria
Dueñas, María
Picón, María J.
Marcos, Ascensión
Nova, Esther
author_sort Gómez-Martínez, Sonia
collection PubMed
description Moringa oleifera (MO) is a multipurpose plant with a high polyphenol content, which is being increasingly consumed to lessen the risk of chronic metabolic diseases such as Type 2 diabetes; however, scientific evidence from clinical trials is scarce. A double-blind, randomized, placebo-controlled, parallel group intervention study with MO leaves as a food supplement was conducted in subjects with prediabetes. They consumed six daily capsules of MO dry leaf powder (2400 mg/day) (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Glycemia, appetite-controlling hormones and gut microbiota composition were studied. ANCOVA with the fixed factor “treatment” and the basal value as covariate was used to compare the change score between the groups. The results showed significant differences between groups in the rate of change of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c), which showed opposite directions during the intervention, decreasing in MO and increasing in PLC. No different change scores were found between the groups in microbiota, hepatic and renal function markers or the appetite-controlling hormones measured. In conclusion, MO supplementation resulted in favorable changes in glycaemia markers compared to placebo in the subjects with prediabetes studied, suggesting that MO might act as a natural antihyperglycemic agent.
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spelling pubmed-87462992022-01-11 Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes Gómez-Martínez, Sonia Díaz-Prieto, Ligia E. Castro, Iván Vicente Jurado, César Iturmendi, Nerea Martín-Ridaura, Maria Carmen Calle, Nuria Dueñas, María Picón, María J. Marcos, Ascensión Nova, Esther Nutrients Article Moringa oleifera (MO) is a multipurpose plant with a high polyphenol content, which is being increasingly consumed to lessen the risk of chronic metabolic diseases such as Type 2 diabetes; however, scientific evidence from clinical trials is scarce. A double-blind, randomized, placebo-controlled, parallel group intervention study with MO leaves as a food supplement was conducted in subjects with prediabetes. They consumed six daily capsules of MO dry leaf powder (2400 mg/day) (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Glycemia, appetite-controlling hormones and gut microbiota composition were studied. ANCOVA with the fixed factor “treatment” and the basal value as covariate was used to compare the change score between the groups. The results showed significant differences between groups in the rate of change of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c), which showed opposite directions during the intervention, decreasing in MO and increasing in PLC. No different change scores were found between the groups in microbiota, hepatic and renal function markers or the appetite-controlling hormones measured. In conclusion, MO supplementation resulted in favorable changes in glycaemia markers compared to placebo in the subjects with prediabetes studied, suggesting that MO might act as a natural antihyperglycemic agent. MDPI 2021-12-24 /pmc/articles/PMC8746299/ /pubmed/35010932 http://dx.doi.org/10.3390/nu14010057 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gómez-Martínez, Sonia
Díaz-Prieto, Ligia E.
Castro, Iván Vicente
Jurado, César
Iturmendi, Nerea
Martín-Ridaura, Maria Carmen
Calle, Nuria
Dueñas, María
Picón, María J.
Marcos, Ascensión
Nova, Esther
Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
title Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
title_full Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
title_fullStr Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
title_full_unstemmed Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
title_short Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
title_sort moringa oleifera leaf supplementation as a glycemic control strategy in subjects with prediabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746299/
https://www.ncbi.nlm.nih.gov/pubmed/35010932
http://dx.doi.org/10.3390/nu14010057
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