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Evaluation of Virtual Screening Strategies for the Identification of γ-Secretase Inhibitors and Modulators

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progress...

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Detalles Bibliográficos
Autores principales:	Ioppolo, Alicia, Eccles, Melissa, Groth, David, Verdile, Giuseppe, Agostino, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746326/ https://www.ncbi.nlm.nih.gov/pubmed/35011410 http://dx.doi.org/10.3390/molecules27010176

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