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Alternative Targets for Modulators of Mitochondrial Potassium Channels

Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS). It has been found that pharmacological activation of mitochondrial potassium channels durin...

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Detalles Bibliográficos
Autores principales: Wrzosek, Antoni, Gałecka, Shur, Żochowska, Monika, Olszewska, Anna, Kulawiak, Bogusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746388/
https://www.ncbi.nlm.nih.gov/pubmed/35011530
http://dx.doi.org/10.3390/molecules27010299
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author Wrzosek, Antoni
Gałecka, Shur
Żochowska, Monika
Olszewska, Anna
Kulawiak, Bogusz
author_facet Wrzosek, Antoni
Gałecka, Shur
Żochowska, Monika
Olszewska, Anna
Kulawiak, Bogusz
author_sort Wrzosek, Antoni
collection PubMed
description Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS). It has been found that pharmacological activation of mitochondrial potassium channels during ischemia/reperfusion (I/R) injury activates cytoprotective mechanisms resulting in increased cell survival. In cancer cells, the inhibition of these channels leads to increased cell death. Therefore, mitochondrial potassium channels are intriguing targets for the development of new pharmacological strategies. In most cases, however, the substances that modulate the mitochondrial potassium channels have a few alternative targets in the cell. This may result in unexpected or unwanted effects induced by these compounds. In our review, we briefly present the various classes of mitochondrial potassium (mitoK) channels and describe the chemical compounds that modulate their activity. We also describe examples of the multidirectional activity of the activators and inhibitors of mitochondrial potassium channels.
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spelling pubmed-87463882022-01-11 Alternative Targets for Modulators of Mitochondrial Potassium Channels Wrzosek, Antoni Gałecka, Shur Żochowska, Monika Olszewska, Anna Kulawiak, Bogusz Molecules Review Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS). It has been found that pharmacological activation of mitochondrial potassium channels during ischemia/reperfusion (I/R) injury activates cytoprotective mechanisms resulting in increased cell survival. In cancer cells, the inhibition of these channels leads to increased cell death. Therefore, mitochondrial potassium channels are intriguing targets for the development of new pharmacological strategies. In most cases, however, the substances that modulate the mitochondrial potassium channels have a few alternative targets in the cell. This may result in unexpected or unwanted effects induced by these compounds. In our review, we briefly present the various classes of mitochondrial potassium (mitoK) channels and describe the chemical compounds that modulate their activity. We also describe examples of the multidirectional activity of the activators and inhibitors of mitochondrial potassium channels. MDPI 2022-01-04 /pmc/articles/PMC8746388/ /pubmed/35011530 http://dx.doi.org/10.3390/molecules27010299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wrzosek, Antoni
Gałecka, Shur
Żochowska, Monika
Olszewska, Anna
Kulawiak, Bogusz
Alternative Targets for Modulators of Mitochondrial Potassium Channels
title Alternative Targets for Modulators of Mitochondrial Potassium Channels
title_full Alternative Targets for Modulators of Mitochondrial Potassium Channels
title_fullStr Alternative Targets for Modulators of Mitochondrial Potassium Channels
title_full_unstemmed Alternative Targets for Modulators of Mitochondrial Potassium Channels
title_short Alternative Targets for Modulators of Mitochondrial Potassium Channels
title_sort alternative targets for modulators of mitochondrial potassium channels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746388/
https://www.ncbi.nlm.nih.gov/pubmed/35011530
http://dx.doi.org/10.3390/molecules27010299
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