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Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins
Macrophages have diverse functions in the pathogenesis, resolution, and repair of inflammatory processes. Elegant studies have elucidated the metabolomic and transcriptomic profiles of activated macrophages. However, the versatility of macrophage responses in inflammation is likely due, at least in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746402/ https://www.ncbi.nlm.nih.gov/pubmed/35011385 http://dx.doi.org/10.3390/molecules27010152 |
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author | Balestrieri, Barbara Di Costanzo, David Dwyer, Daniel F. |
author_facet | Balestrieri, Barbara Di Costanzo, David Dwyer, Daniel F. |
author_sort | Balestrieri, Barbara |
collection | PubMed |
description | Macrophages have diverse functions in the pathogenesis, resolution, and repair of inflammatory processes. Elegant studies have elucidated the metabolomic and transcriptomic profiles of activated macrophages. However, the versatility of macrophage responses in inflammation is likely due, at least in part, to their ability to rearrange their repertoire of bioactive lipids, including fatty acids and oxylipins. This review will describe the fatty acids and oxylipins generated by macrophages and their role in type 1 and type 2 immune responses. We will highlight lipidomic studies that have shaped the current understanding of the role of lipids in macrophage polarization. |
format | Online Article Text |
id | pubmed-8746402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87464022022-01-11 Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins Balestrieri, Barbara Di Costanzo, David Dwyer, Daniel F. Molecules Review Macrophages have diverse functions in the pathogenesis, resolution, and repair of inflammatory processes. Elegant studies have elucidated the metabolomic and transcriptomic profiles of activated macrophages. However, the versatility of macrophage responses in inflammation is likely due, at least in part, to their ability to rearrange their repertoire of bioactive lipids, including fatty acids and oxylipins. This review will describe the fatty acids and oxylipins generated by macrophages and their role in type 1 and type 2 immune responses. We will highlight lipidomic studies that have shaped the current understanding of the role of lipids in macrophage polarization. MDPI 2021-12-28 /pmc/articles/PMC8746402/ /pubmed/35011385 http://dx.doi.org/10.3390/molecules27010152 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Balestrieri, Barbara Di Costanzo, David Dwyer, Daniel F. Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins |
title | Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins |
title_full | Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins |
title_fullStr | Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins |
title_full_unstemmed | Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins |
title_short | Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins |
title_sort | macrophage-mediated immune responses: from fatty acids to oxylipins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746402/ https://www.ncbi.nlm.nih.gov/pubmed/35011385 http://dx.doi.org/10.3390/molecules27010152 |
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