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Stereoelectronic Features of a Complex Ketene Dimerization Reaction

The amidation reaction of a tetrahydroisoquinolin-1-one-4-carboxylic acid is a key step in the multi-kilogram-scale preparation of the antimalarial drug SJ733, now in phase 2 clinical trials. In the course of investigating THIQ carboxamidations, we found that propanephosphonic acid anhydride (T3P) i...

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Detalles Bibliográficos
Autores principales:	Barrows, Robert D., Dresel, Mark J., Emge, Thomas J., Rablen, Paul R., Knapp, Spencer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746406/ https://www.ncbi.nlm.nih.gov/pubmed/35011298 http://dx.doi.org/10.3390/molecules27010066

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