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Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the bioco...

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Autores principales: Garanina, Anastasiia S., Nikitin, Alexey A., Abakumova, Tatiana O., Semkina, Alevtina S., Prelovskaya, Alexandra O., Naumenko, Victor A., Erofeev, Alexander S., Gorelkin, Peter V., Majouga, Alexander G., Abakumov, Maxim A., Wiedwald, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746458/
https://www.ncbi.nlm.nih.gov/pubmed/35009988
http://dx.doi.org/10.3390/nano12010038
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author Garanina, Anastasiia S.
Nikitin, Alexey A.
Abakumova, Tatiana O.
Semkina, Alevtina S.
Prelovskaya, Alexandra O.
Naumenko, Victor A.
Erofeev, Alexander S.
Gorelkin, Peter V.
Majouga, Alexander G.
Abakumov, Maxim A.
Wiedwald, Ulf
author_facet Garanina, Anastasiia S.
Nikitin, Alexey A.
Abakumova, Tatiana O.
Semkina, Alevtina S.
Prelovskaya, Alexandra O.
Naumenko, Victor A.
Erofeev, Alexander S.
Gorelkin, Peter V.
Majouga, Alexander G.
Abakumov, Maxim A.
Wiedwald, Ulf
author_sort Garanina, Anastasiia S.
collection PubMed
description Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g(−1). Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.
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spelling pubmed-87464582022-01-11 Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity Garanina, Anastasiia S. Nikitin, Alexey A. Abakumova, Tatiana O. Semkina, Alevtina S. Prelovskaya, Alexandra O. Naumenko, Victor A. Erofeev, Alexander S. Gorelkin, Peter V. Majouga, Alexander G. Abakumov, Maxim A. Wiedwald, Ulf Nanomaterials (Basel) Article Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g(−1). Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained. MDPI 2021-12-23 /pmc/articles/PMC8746458/ /pubmed/35009988 http://dx.doi.org/10.3390/nano12010038 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Garanina, Anastasiia S.
Nikitin, Alexey A.
Abakumova, Tatiana O.
Semkina, Alevtina S.
Prelovskaya, Alexandra O.
Naumenko, Victor A.
Erofeev, Alexander S.
Gorelkin, Peter V.
Majouga, Alexander G.
Abakumov, Maxim A.
Wiedwald, Ulf
Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
title Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
title_full Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
title_fullStr Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
title_full_unstemmed Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
title_short Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
title_sort cobalt ferrite nanoparticles for tumor therapy: effective heating versus possible toxicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746458/
https://www.ncbi.nlm.nih.gov/pubmed/35009988
http://dx.doi.org/10.3390/nano12010038
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