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The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746471/ https://www.ncbi.nlm.nih.gov/pubmed/35011543 http://dx.doi.org/10.3390/molecules27010311 |
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author | Gao, Zhengyin Lei, Weng I Lee, Leo Tsz On |
author_facet | Gao, Zhengyin Lei, Weng I Lee, Leo Tsz On |
author_sort | Gao, Zhengyin |
collection | PubMed |
description | Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research. |
format | Online Article Text |
id | pubmed-8746471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87464712022-01-11 The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells Gao, Zhengyin Lei, Weng I Lee, Leo Tsz On Molecules Review Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research. MDPI 2022-01-05 /pmc/articles/PMC8746471/ /pubmed/35011543 http://dx.doi.org/10.3390/molecules27010311 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gao, Zhengyin Lei, Weng I Lee, Leo Tsz On The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
title | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
title_full | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
title_fullStr | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
title_full_unstemmed | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
title_short | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
title_sort | role of neuropeptide-stimulated camp-epacs signalling in cancer cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746471/ https://www.ncbi.nlm.nih.gov/pubmed/35011543 http://dx.doi.org/10.3390/molecules27010311 |
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