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The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells

Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the...

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Detalles Bibliográficos
Autores principales: Gao, Zhengyin, Lei, Weng I, Lee, Leo Tsz On
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746471/
https://www.ncbi.nlm.nih.gov/pubmed/35011543
http://dx.doi.org/10.3390/molecules27010311
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author Gao, Zhengyin
Lei, Weng I
Lee, Leo Tsz On
author_facet Gao, Zhengyin
Lei, Weng I
Lee, Leo Tsz On
author_sort Gao, Zhengyin
collection PubMed
description Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research.
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spelling pubmed-87464712022-01-11 The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells Gao, Zhengyin Lei, Weng I Lee, Leo Tsz On Molecules Review Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research. MDPI 2022-01-05 /pmc/articles/PMC8746471/ /pubmed/35011543 http://dx.doi.org/10.3390/molecules27010311 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Zhengyin
Lei, Weng I
Lee, Leo Tsz On
The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
title The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
title_full The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
title_fullStr The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
title_full_unstemmed The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
title_short The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
title_sort role of neuropeptide-stimulated camp-epacs signalling in cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746471/
https://www.ncbi.nlm.nih.gov/pubmed/35011543
http://dx.doi.org/10.3390/molecules27010311
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