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Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechani...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746526/ https://www.ncbi.nlm.nih.gov/pubmed/35011482 http://dx.doi.org/10.3390/molecules27010251 |
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author | Khan, Imran Ahmad Hussain, Musaddique Syed, Shahzada Khurram Saadullah, Malik Alqahtani, Ali M. Alqahtani, Taha Aldahish, Afaf A. Asiri, Saeed Zeng, Ling-Hui |
author_facet | Khan, Imran Ahmad Hussain, Musaddique Syed, Shahzada Khurram Saadullah, Malik Alqahtani, Ali M. Alqahtani, Taha Aldahish, Afaf A. Asiri, Saeed Zeng, Ling-Hui |
author_sort | Khan, Imran Ahmad |
collection | PubMed |
description | Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects of crude leaf extract of P. rubra were observed in rabbit aorta ring preparations. Hypotensive effects were measured using pressure and force transducers connected to the Power Lab data acquisition system. Furthermore, P. rubra displayed cardioprotective properties in rabbits when they were exposed to adrenaline-induced myocardial infarction. In comparison to the intoxicated group, the myocardial infarction model showed decreased troponin levels, CK-MB, LDH, ALT, ALP, AST, and CRP, as well as necrosis, apoptosis, oedema, and inflammatory cell enrollment. P. rubra has revealed good antioxidant properties and prolonged the noradrenaline intoxicated platelet adhesion. Its anticoagulant, vasorelaxant, and cardioprotective effects in both in vivo and ex vivo investigations are enabled by blocking L-type calcium channels, lowering adrenaline, induced oxidative stress, and tissue tear, justifying its therapeutic utility in cardiovascular disorders. |
format | Online Article Text |
id | pubmed-8746526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87465262022-01-11 Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders Khan, Imran Ahmad Hussain, Musaddique Syed, Shahzada Khurram Saadullah, Malik Alqahtani, Ali M. Alqahtani, Taha Aldahish, Afaf A. Asiri, Saeed Zeng, Ling-Hui Molecules Article Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects of crude leaf extract of P. rubra were observed in rabbit aorta ring preparations. Hypotensive effects were measured using pressure and force transducers connected to the Power Lab data acquisition system. Furthermore, P. rubra displayed cardioprotective properties in rabbits when they were exposed to adrenaline-induced myocardial infarction. In comparison to the intoxicated group, the myocardial infarction model showed decreased troponin levels, CK-MB, LDH, ALT, ALP, AST, and CRP, as well as necrosis, apoptosis, oedema, and inflammatory cell enrollment. P. rubra has revealed good antioxidant properties and prolonged the noradrenaline intoxicated platelet adhesion. Its anticoagulant, vasorelaxant, and cardioprotective effects in both in vivo and ex vivo investigations are enabled by blocking L-type calcium channels, lowering adrenaline, induced oxidative stress, and tissue tear, justifying its therapeutic utility in cardiovascular disorders. MDPI 2021-12-31 /pmc/articles/PMC8746526/ /pubmed/35011482 http://dx.doi.org/10.3390/molecules27010251 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khan, Imran Ahmad Hussain, Musaddique Syed, Shahzada Khurram Saadullah, Malik Alqahtani, Ali M. Alqahtani, Taha Aldahish, Afaf A. Asiri, Saeed Zeng, Ling-Hui Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders |
title | Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders |
title_full | Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders |
title_fullStr | Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders |
title_full_unstemmed | Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders |
title_short | Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders |
title_sort | pharmacological justification for the medicinal use of plumeria rubra linn. in cardiovascular disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746526/ https://www.ncbi.nlm.nih.gov/pubmed/35011482 http://dx.doi.org/10.3390/molecules27010251 |
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