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Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders

Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechani...

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Autores principales: Khan, Imran Ahmad, Hussain, Musaddique, Syed, Shahzada Khurram, Saadullah, Malik, Alqahtani, Ali M., Alqahtani, Taha, Aldahish, Afaf A., Asiri, Saeed, Zeng, Ling-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746526/
https://www.ncbi.nlm.nih.gov/pubmed/35011482
http://dx.doi.org/10.3390/molecules27010251
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author Khan, Imran Ahmad
Hussain, Musaddique
Syed, Shahzada Khurram
Saadullah, Malik
Alqahtani, Ali M.
Alqahtani, Taha
Aldahish, Afaf A.
Asiri, Saeed
Zeng, Ling-Hui
author_facet Khan, Imran Ahmad
Hussain, Musaddique
Syed, Shahzada Khurram
Saadullah, Malik
Alqahtani, Ali M.
Alqahtani, Taha
Aldahish, Afaf A.
Asiri, Saeed
Zeng, Ling-Hui
author_sort Khan, Imran Ahmad
collection PubMed
description Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects of crude leaf extract of P. rubra were observed in rabbit aorta ring preparations. Hypotensive effects were measured using pressure and force transducers connected to the Power Lab data acquisition system. Furthermore, P. rubra displayed cardioprotective properties in rabbits when they were exposed to adrenaline-induced myocardial infarction. In comparison to the intoxicated group, the myocardial infarction model showed decreased troponin levels, CK-MB, LDH, ALT, ALP, AST, and CRP, as well as necrosis, apoptosis, oedema, and inflammatory cell enrollment. P. rubra has revealed good antioxidant properties and prolonged the noradrenaline intoxicated platelet adhesion. Its anticoagulant, vasorelaxant, and cardioprotective effects in both in vivo and ex vivo investigations are enabled by blocking L-type calcium channels, lowering adrenaline, induced oxidative stress, and tissue tear, justifying its therapeutic utility in cardiovascular disorders.
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spelling pubmed-87465262022-01-11 Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders Khan, Imran Ahmad Hussain, Musaddique Syed, Shahzada Khurram Saadullah, Malik Alqahtani, Ali M. Alqahtani, Taha Aldahish, Afaf A. Asiri, Saeed Zeng, Ling-Hui Molecules Article Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P. rubra in cardiovascular illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects of crude leaf extract of P. rubra were observed in rabbit aorta ring preparations. Hypotensive effects were measured using pressure and force transducers connected to the Power Lab data acquisition system. Furthermore, P. rubra displayed cardioprotective properties in rabbits when they were exposed to adrenaline-induced myocardial infarction. In comparison to the intoxicated group, the myocardial infarction model showed decreased troponin levels, CK-MB, LDH, ALT, ALP, AST, and CRP, as well as necrosis, apoptosis, oedema, and inflammatory cell enrollment. P. rubra has revealed good antioxidant properties and prolonged the noradrenaline intoxicated platelet adhesion. Its anticoagulant, vasorelaxant, and cardioprotective effects in both in vivo and ex vivo investigations are enabled by blocking L-type calcium channels, lowering adrenaline, induced oxidative stress, and tissue tear, justifying its therapeutic utility in cardiovascular disorders. MDPI 2021-12-31 /pmc/articles/PMC8746526/ /pubmed/35011482 http://dx.doi.org/10.3390/molecules27010251 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khan, Imran Ahmad
Hussain, Musaddique
Syed, Shahzada Khurram
Saadullah, Malik
Alqahtani, Ali M.
Alqahtani, Taha
Aldahish, Afaf A.
Asiri, Saeed
Zeng, Ling-Hui
Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
title Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
title_full Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
title_fullStr Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
title_full_unstemmed Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
title_short Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
title_sort pharmacological justification for the medicinal use of plumeria rubra linn. in cardiovascular disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746526/
https://www.ncbi.nlm.nih.gov/pubmed/35011482
http://dx.doi.org/10.3390/molecules27010251
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