Cargando…
Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates
The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show the production of cost-effective SERS sensors obtained...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746616/ https://www.ncbi.nlm.nih.gov/pubmed/35011263 http://dx.doi.org/10.3390/molecules27010030 |
_version_ | 1784630630161580032 |
---|---|
author | Macrelli, Andrea Villa, Nicolò Simone Lucotti, Andrea Dellasega, David Ossi, Paolo Maria Tommasini, Matteo |
author_facet | Macrelli, Andrea Villa, Nicolò Simone Lucotti, Andrea Dellasega, David Ossi, Paolo Maria Tommasini, Matteo |
author_sort | Macrelli, Andrea |
collection | PubMed |
description | The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show the production of cost-effective SERS sensors obtained by depositing Lee-Meisel Ag colloids on filter paper either by natural sedimentation or centrifugation. We have characterized the morphological and plasmonic features of the sensors by optical microscopy, SEM, and UV-Vis spectroscopy. Such sensors can be used to quantify by SERS the anti-epileptic drug Perampanel (in the concentration range 1 × 10(−4)–5 × 10(−6) M) by spinning them during the micro-Raman measurements on the top of a custom device obtained from spare part hard disk drives. This approach minimizes laser-induced heating effects and allows averaging over the spatial non-uniformity of the sensor. |
format | Online Article Text |
id | pubmed-8746616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87466162022-01-11 Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates Macrelli, Andrea Villa, Nicolò Simone Lucotti, Andrea Dellasega, David Ossi, Paolo Maria Tommasini, Matteo Molecules Article The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show the production of cost-effective SERS sensors obtained by depositing Lee-Meisel Ag colloids on filter paper either by natural sedimentation or centrifugation. We have characterized the morphological and plasmonic features of the sensors by optical microscopy, SEM, and UV-Vis spectroscopy. Such sensors can be used to quantify by SERS the anti-epileptic drug Perampanel (in the concentration range 1 × 10(−4)–5 × 10(−6) M) by spinning them during the micro-Raman measurements on the top of a custom device obtained from spare part hard disk drives. This approach minimizes laser-induced heating effects and allows averaging over the spatial non-uniformity of the sensor. MDPI 2021-12-22 /pmc/articles/PMC8746616/ /pubmed/35011263 http://dx.doi.org/10.3390/molecules27010030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Macrelli, Andrea Villa, Nicolò Simone Lucotti, Andrea Dellasega, David Ossi, Paolo Maria Tommasini, Matteo Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates |
title | Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates |
title_full | Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates |
title_fullStr | Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates |
title_full_unstemmed | Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates |
title_short | Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates |
title_sort | sensing the anti-epileptic drug perampanel with paper-based spinning sers substrates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746616/ https://www.ncbi.nlm.nih.gov/pubmed/35011263 http://dx.doi.org/10.3390/molecules27010030 |
work_keys_str_mv | AT macrelliandrea sensingtheantiepilepticdrugperampanelwithpaperbasedspinningserssubstrates AT villanicolosimone sensingtheantiepilepticdrugperampanelwithpaperbasedspinningserssubstrates AT lucottiandrea sensingtheantiepilepticdrugperampanelwithpaperbasedspinningserssubstrates AT dellasegadavid sensingtheantiepilepticdrugperampanelwithpaperbasedspinningserssubstrates AT ossipaolomaria sensingtheantiepilepticdrugperampanelwithpaperbasedspinningserssubstrates AT tommasinimatteo sensingtheantiepilepticdrugperampanelwithpaperbasedspinningserssubstrates |