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Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?

Transgelin is a 22-kDa protein involved in cytoskeletal organization and expressed in smooth muscle tissue. According to animal studies, it is a potential mediator of kidney injury and fibrosis, and moreover, its role in tumorigenesis is emerging in a variety of cancers. The study included 126 ambul...

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Autores principales: Woziwodzka, Karolina, Małyszko, Jolanta, Koc-Żórawska, Ewa, Żórawski, Marcin, Dumnicka, Paulina, Jurczyszyn, Artur, Batko, Krzysztof, Mazur, Paulina, Banaszkiewicz, Małgorzata, Krzanowski, Marcin, Gołasa, Paulina, Małyszko, Jacek A., Drożdż, Ryszard, Krzanowska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746652/
https://www.ncbi.nlm.nih.gov/pubmed/35011306
http://dx.doi.org/10.3390/molecules27010079
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author Woziwodzka, Karolina
Małyszko, Jolanta
Koc-Żórawska, Ewa
Żórawski, Marcin
Dumnicka, Paulina
Jurczyszyn, Artur
Batko, Krzysztof
Mazur, Paulina
Banaszkiewicz, Małgorzata
Krzanowski, Marcin
Gołasa, Paulina
Małyszko, Jacek A.
Drożdż, Ryszard
Krzanowska, Katarzyna
author_facet Woziwodzka, Karolina
Małyszko, Jolanta
Koc-Żórawska, Ewa
Żórawski, Marcin
Dumnicka, Paulina
Jurczyszyn, Artur
Batko, Krzysztof
Mazur, Paulina
Banaszkiewicz, Małgorzata
Krzanowski, Marcin
Gołasa, Paulina
Małyszko, Jacek A.
Drożdż, Ryszard
Krzanowska, Katarzyna
author_sort Woziwodzka, Karolina
collection PubMed
description Transgelin is a 22-kDa protein involved in cytoskeletal organization and expressed in smooth muscle tissue. According to animal studies, it is a potential mediator of kidney injury and fibrosis, and moreover, its role in tumorigenesis is emerging in a variety of cancers. The study included 126 ambulatory patients with multiple myeloma (MM). Serum transgelin-2 concentrations were measured by enzyme-linked immunoassay. We evaluated associations between baseline transgelin and kidney function (serum creatinine, estimated glomerular filtration rate—eGFR, urinary markers of tubular injury: cystatin-C, neutrophil gelatinase associated lipocalin—NGAL monomer, cell cycle arrest biomarkers IGFBP-7 and TIMP-2) and markers of MM burden. Baseline serum transgelin was also evaluated as a predictor of kidney function after a follow-up of 27 months from the start of the study. Significant correlations were detected between serum transgelin-2 and serum creatinine (R = 0.29; p = 0.001) and eGFR (R = −0.25; p = 0.007). Transgelin significantly correlated with serum free light chains lambda (R = 0.18; p = 0.047) and serum periostin (R = −0.22; p = 0.013), after exclusion of smoldering MM patients. Patients with decreasing eGFR had higher transgelin levels (median 106.6 versus 83.9 ng/mL), although the difference was marginally significant (p = 0.05). However, baseline transgelin positively correlated with serum creatinine after the follow-up period (R = 0.37; p < 0.001) and negatively correlated with eGFR after the follow-up period (R = −0.33; p < 0.001). Moreover, higher baseline serum transgelin (beta = −0.11 ± 0.05; p = 0.032) significantly predicted lower eGFR values after the follow-up period, irrespective of baseline eGFR and follow-up duration. Our study shows for the first time that elevated serum transgelin is negatively associated with glomerular filtration in MM and predicts a decline in renal function over long-term follow-up.
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spelling pubmed-87466522022-01-11 Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment? Woziwodzka, Karolina Małyszko, Jolanta Koc-Żórawska, Ewa Żórawski, Marcin Dumnicka, Paulina Jurczyszyn, Artur Batko, Krzysztof Mazur, Paulina Banaszkiewicz, Małgorzata Krzanowski, Marcin Gołasa, Paulina Małyszko, Jacek A. Drożdż, Ryszard Krzanowska, Katarzyna Molecules Article Transgelin is a 22-kDa protein involved in cytoskeletal organization and expressed in smooth muscle tissue. According to animal studies, it is a potential mediator of kidney injury and fibrosis, and moreover, its role in tumorigenesis is emerging in a variety of cancers. The study included 126 ambulatory patients with multiple myeloma (MM). Serum transgelin-2 concentrations were measured by enzyme-linked immunoassay. We evaluated associations between baseline transgelin and kidney function (serum creatinine, estimated glomerular filtration rate—eGFR, urinary markers of tubular injury: cystatin-C, neutrophil gelatinase associated lipocalin—NGAL monomer, cell cycle arrest biomarkers IGFBP-7 and TIMP-2) and markers of MM burden. Baseline serum transgelin was also evaluated as a predictor of kidney function after a follow-up of 27 months from the start of the study. Significant correlations were detected between serum transgelin-2 and serum creatinine (R = 0.29; p = 0.001) and eGFR (R = −0.25; p = 0.007). Transgelin significantly correlated with serum free light chains lambda (R = 0.18; p = 0.047) and serum periostin (R = −0.22; p = 0.013), after exclusion of smoldering MM patients. Patients with decreasing eGFR had higher transgelin levels (median 106.6 versus 83.9 ng/mL), although the difference was marginally significant (p = 0.05). However, baseline transgelin positively correlated with serum creatinine after the follow-up period (R = 0.37; p < 0.001) and negatively correlated with eGFR after the follow-up period (R = −0.33; p < 0.001). Moreover, higher baseline serum transgelin (beta = −0.11 ± 0.05; p = 0.032) significantly predicted lower eGFR values after the follow-up period, irrespective of baseline eGFR and follow-up duration. Our study shows for the first time that elevated serum transgelin is negatively associated with glomerular filtration in MM and predicts a decline in renal function over long-term follow-up. MDPI 2021-12-23 /pmc/articles/PMC8746652/ /pubmed/35011306 http://dx.doi.org/10.3390/molecules27010079 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Woziwodzka, Karolina
Małyszko, Jolanta
Koc-Żórawska, Ewa
Żórawski, Marcin
Dumnicka, Paulina
Jurczyszyn, Artur
Batko, Krzysztof
Mazur, Paulina
Banaszkiewicz, Małgorzata
Krzanowski, Marcin
Gołasa, Paulina
Małyszko, Jacek A.
Drożdż, Ryszard
Krzanowska, Katarzyna
Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
title Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
title_full Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
title_fullStr Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
title_full_unstemmed Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
title_short Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
title_sort transgelin-2 in multiple myeloma: a new marker of renal impairment?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746652/
https://www.ncbi.nlm.nih.gov/pubmed/35011306
http://dx.doi.org/10.3390/molecules27010079
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