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Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review
Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment therape...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746670/ https://www.ncbi.nlm.nih.gov/pubmed/35011376 http://dx.doi.org/10.3390/molecules27010146 |
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author | Kenchegowda, Madhuchandra Rahamathulla, Mohamed Hani, Umme Begum, Mohammed Y. Guruswamy, Sagar Osmani, Riyaz Ali M. Gowrav, Mysore P. Alshehri, Sultan Ghoneim, Mohammed M. Alshlowi, Areej Gowda, Devegowda V. |
author_facet | Kenchegowda, Madhuchandra Rahamathulla, Mohamed Hani, Umme Begum, Mohammed Y. Guruswamy, Sagar Osmani, Riyaz Ali M. Gowrav, Mysore P. Alshehri, Sultan Ghoneim, Mohammed M. Alshlowi, Areej Gowda, Devegowda V. |
author_sort | Kenchegowda, Madhuchandra |
collection | PubMed |
description | Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment therapeutic efficacy. The focal point of research remains to develop new-fangled smart nanocarriers that can selectively respond to cancer-specific conditions and deliver medications to target cells efficiently. Nanocarriers deliver loaded therapeutic cargos to the tumour site either in a passive or active mode, with the least drug elimination from the drug delivery systems. This review chiefly focuses on current advances allied to smart nanocarriers such as dendrimers, liposomes, mesoporous silica nanoparticles, quantum dots, micelles, superparamagnetic iron-oxide nanoparticles, gold nanoparticles and carbon nanotubes, to list a few. Exhaustive discussion on crucial topics like drug targeting, surface decorated smart-nanocarriers and stimuli-responsive cancer nanotherapeutics responding to temperature, enzyme, pH and redox stimuli have been covered. |
format | Online Article Text |
id | pubmed-8746670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87466702022-01-11 Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review Kenchegowda, Madhuchandra Rahamathulla, Mohamed Hani, Umme Begum, Mohammed Y. Guruswamy, Sagar Osmani, Riyaz Ali M. Gowrav, Mysore P. Alshehri, Sultan Ghoneim, Mohammed M. Alshlowi, Areej Gowda, Devegowda V. Molecules Review Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment therapeutic efficacy. The focal point of research remains to develop new-fangled smart nanocarriers that can selectively respond to cancer-specific conditions and deliver medications to target cells efficiently. Nanocarriers deliver loaded therapeutic cargos to the tumour site either in a passive or active mode, with the least drug elimination from the drug delivery systems. This review chiefly focuses on current advances allied to smart nanocarriers such as dendrimers, liposomes, mesoporous silica nanoparticles, quantum dots, micelles, superparamagnetic iron-oxide nanoparticles, gold nanoparticles and carbon nanotubes, to list a few. Exhaustive discussion on crucial topics like drug targeting, surface decorated smart-nanocarriers and stimuli-responsive cancer nanotherapeutics responding to temperature, enzyme, pH and redox stimuli have been covered. MDPI 2021-12-27 /pmc/articles/PMC8746670/ /pubmed/35011376 http://dx.doi.org/10.3390/molecules27010146 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kenchegowda, Madhuchandra Rahamathulla, Mohamed Hani, Umme Begum, Mohammed Y. Guruswamy, Sagar Osmani, Riyaz Ali M. Gowrav, Mysore P. Alshehri, Sultan Ghoneim, Mohammed M. Alshlowi, Areej Gowda, Devegowda V. Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review |
title | Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review |
title_full | Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review |
title_fullStr | Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review |
title_full_unstemmed | Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review |
title_short | Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review |
title_sort | smart nanocarriers as an emerging platform for cancer therapy: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746670/ https://www.ncbi.nlm.nih.gov/pubmed/35011376 http://dx.doi.org/10.3390/molecules27010146 |
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