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Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients

This study evaluated the association of the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) with mortality in incident peritoneal dialysis (PD) patients. We performed a multi-center, prospective cohort study of 630 incident PD patients from 2008 to 2015 in Korea. Par...

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Autores principales: Noh, Hee-Won, Jeon, Yena, Kim, Ji-Hye, Lee, Ga-Young, Jeon, Soo-Jee, Kim, Kyu-Yeun, Lim, Jeong-Hoon, Jung, Hee-Yeon, Choi, Ji-Young, Park, Sun-Hee, Kim, Chan-Duck, Kim, Yong-Lim, Cho, Jang-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746736/
https://www.ncbi.nlm.nih.gov/pubmed/35011019
http://dx.doi.org/10.3390/nu14010144
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author Noh, Hee-Won
Jeon, Yena
Kim, Ji-Hye
Lee, Ga-Young
Jeon, Soo-Jee
Kim, Kyu-Yeun
Lim, Jeong-Hoon
Jung, Hee-Yeon
Choi, Ji-Young
Park, Sun-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Cho, Jang-Hee
author_facet Noh, Hee-Won
Jeon, Yena
Kim, Ji-Hye
Lee, Ga-Young
Jeon, Soo-Jee
Kim, Kyu-Yeun
Lim, Jeong-Hoon
Jung, Hee-Yeon
Choi, Ji-Young
Park, Sun-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Cho, Jang-Hee
author_sort Noh, Hee-Won
collection PubMed
description This study evaluated the association of the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) with mortality in incident peritoneal dialysis (PD) patients. We performed a multi-center, prospective cohort study of 630 incident PD patients from 2008 to 2015 in Korea. Participants were stratified into quintiles according to baseline TC, HDL-C, LDL-C and TC/HDL-C. The association between mortality and each lipid profile was evaluated using multivariate Cox regression analysis. During a median follow-up period of 70.3 ± 25.2 months, 185 deaths were recorded. The highest TC/HDL-C group had the highest body mass index, percentage of diabetes and serum albumin level. Multivariate analysis demonstrated that the highest quintile of TC/HDL-C was associated with increased risk of all-cause mortality (hazard ratio 1.69, 95% confidence interval 1.04–2.76; p = 0.036), whereas TC, HDL-C and LDL-C were not associated with mortality. Linear regression analysis showed a positive correlation between TC/HDL-C and body mass index. Increased serum TC/HDL-C was an independent risk factor for mortality in the subgroup of old age, female, cardiovascular disease and low HDL-C. The single lipid marker of TC or HDL-C was not able to predict mortality in PD patients. However, increased serum TC/HDL-C was independently associated with all-cause mortality in PD patients.
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spelling pubmed-87467362022-01-11 Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients Noh, Hee-Won Jeon, Yena Kim, Ji-Hye Lee, Ga-Young Jeon, Soo-Jee Kim, Kyu-Yeun Lim, Jeong-Hoon Jung, Hee-Yeon Choi, Ji-Young Park, Sun-Hee Kim, Chan-Duck Kim, Yong-Lim Cho, Jang-Hee Nutrients Article This study evaluated the association of the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) with mortality in incident peritoneal dialysis (PD) patients. We performed a multi-center, prospective cohort study of 630 incident PD patients from 2008 to 2015 in Korea. Participants were stratified into quintiles according to baseline TC, HDL-C, LDL-C and TC/HDL-C. The association between mortality and each lipid profile was evaluated using multivariate Cox regression analysis. During a median follow-up period of 70.3 ± 25.2 months, 185 deaths were recorded. The highest TC/HDL-C group had the highest body mass index, percentage of diabetes and serum albumin level. Multivariate analysis demonstrated that the highest quintile of TC/HDL-C was associated with increased risk of all-cause mortality (hazard ratio 1.69, 95% confidence interval 1.04–2.76; p = 0.036), whereas TC, HDL-C and LDL-C were not associated with mortality. Linear regression analysis showed a positive correlation between TC/HDL-C and body mass index. Increased serum TC/HDL-C was an independent risk factor for mortality in the subgroup of old age, female, cardiovascular disease and low HDL-C. The single lipid marker of TC or HDL-C was not able to predict mortality in PD patients. However, increased serum TC/HDL-C was independently associated with all-cause mortality in PD patients. MDPI 2021-12-29 /pmc/articles/PMC8746736/ /pubmed/35011019 http://dx.doi.org/10.3390/nu14010144 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Noh, Hee-Won
Jeon, Yena
Kim, Ji-Hye
Lee, Ga-Young
Jeon, Soo-Jee
Kim, Kyu-Yeun
Lim, Jeong-Hoon
Jung, Hee-Yeon
Choi, Ji-Young
Park, Sun-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Cho, Jang-Hee
Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
title Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
title_full Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
title_fullStr Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
title_full_unstemmed Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
title_short Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
title_sort higher serum total cholesterol to high-density lipoprotein cholesterol ratio is associated with increased mortality among incident peritoneal dialysis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746736/
https://www.ncbi.nlm.nih.gov/pubmed/35011019
http://dx.doi.org/10.3390/nu14010144
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