Cargando…
Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients
This study evaluated the association of the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) with mortality in incident peritoneal dialysis (PD) patients. We performed a multi-center, prospective cohort study of 630 incident PD patients from 2008 to 2015 in Korea. Par...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746736/ https://www.ncbi.nlm.nih.gov/pubmed/35011019 http://dx.doi.org/10.3390/nu14010144 |
_version_ | 1784630660888002560 |
---|---|
author | Noh, Hee-Won Jeon, Yena Kim, Ji-Hye Lee, Ga-Young Jeon, Soo-Jee Kim, Kyu-Yeun Lim, Jeong-Hoon Jung, Hee-Yeon Choi, Ji-Young Park, Sun-Hee Kim, Chan-Duck Kim, Yong-Lim Cho, Jang-Hee |
author_facet | Noh, Hee-Won Jeon, Yena Kim, Ji-Hye Lee, Ga-Young Jeon, Soo-Jee Kim, Kyu-Yeun Lim, Jeong-Hoon Jung, Hee-Yeon Choi, Ji-Young Park, Sun-Hee Kim, Chan-Duck Kim, Yong-Lim Cho, Jang-Hee |
author_sort | Noh, Hee-Won |
collection | PubMed |
description | This study evaluated the association of the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) with mortality in incident peritoneal dialysis (PD) patients. We performed a multi-center, prospective cohort study of 630 incident PD patients from 2008 to 2015 in Korea. Participants were stratified into quintiles according to baseline TC, HDL-C, LDL-C and TC/HDL-C. The association between mortality and each lipid profile was evaluated using multivariate Cox regression analysis. During a median follow-up period of 70.3 ± 25.2 months, 185 deaths were recorded. The highest TC/HDL-C group had the highest body mass index, percentage of diabetes and serum albumin level. Multivariate analysis demonstrated that the highest quintile of TC/HDL-C was associated with increased risk of all-cause mortality (hazard ratio 1.69, 95% confidence interval 1.04–2.76; p = 0.036), whereas TC, HDL-C and LDL-C were not associated with mortality. Linear regression analysis showed a positive correlation between TC/HDL-C and body mass index. Increased serum TC/HDL-C was an independent risk factor for mortality in the subgroup of old age, female, cardiovascular disease and low HDL-C. The single lipid marker of TC or HDL-C was not able to predict mortality in PD patients. However, increased serum TC/HDL-C was independently associated with all-cause mortality in PD patients. |
format | Online Article Text |
id | pubmed-8746736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87467362022-01-11 Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients Noh, Hee-Won Jeon, Yena Kim, Ji-Hye Lee, Ga-Young Jeon, Soo-Jee Kim, Kyu-Yeun Lim, Jeong-Hoon Jung, Hee-Yeon Choi, Ji-Young Park, Sun-Hee Kim, Chan-Duck Kim, Yong-Lim Cho, Jang-Hee Nutrients Article This study evaluated the association of the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) with mortality in incident peritoneal dialysis (PD) patients. We performed a multi-center, prospective cohort study of 630 incident PD patients from 2008 to 2015 in Korea. Participants were stratified into quintiles according to baseline TC, HDL-C, LDL-C and TC/HDL-C. The association between mortality and each lipid profile was evaluated using multivariate Cox regression analysis. During a median follow-up period of 70.3 ± 25.2 months, 185 deaths were recorded. The highest TC/HDL-C group had the highest body mass index, percentage of diabetes and serum albumin level. Multivariate analysis demonstrated that the highest quintile of TC/HDL-C was associated with increased risk of all-cause mortality (hazard ratio 1.69, 95% confidence interval 1.04–2.76; p = 0.036), whereas TC, HDL-C and LDL-C were not associated with mortality. Linear regression analysis showed a positive correlation between TC/HDL-C and body mass index. Increased serum TC/HDL-C was an independent risk factor for mortality in the subgroup of old age, female, cardiovascular disease and low HDL-C. The single lipid marker of TC or HDL-C was not able to predict mortality in PD patients. However, increased serum TC/HDL-C was independently associated with all-cause mortality in PD patients. MDPI 2021-12-29 /pmc/articles/PMC8746736/ /pubmed/35011019 http://dx.doi.org/10.3390/nu14010144 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Noh, Hee-Won Jeon, Yena Kim, Ji-Hye Lee, Ga-Young Jeon, Soo-Jee Kim, Kyu-Yeun Lim, Jeong-Hoon Jung, Hee-Yeon Choi, Ji-Young Park, Sun-Hee Kim, Chan-Duck Kim, Yong-Lim Cho, Jang-Hee Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients |
title | Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients |
title_full | Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients |
title_fullStr | Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients |
title_full_unstemmed | Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients |
title_short | Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients |
title_sort | higher serum total cholesterol to high-density lipoprotein cholesterol ratio is associated with increased mortality among incident peritoneal dialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746736/ https://www.ncbi.nlm.nih.gov/pubmed/35011019 http://dx.doi.org/10.3390/nu14010144 |
work_keys_str_mv | AT nohheewon higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT jeonyena higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT kimjihye higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT leegayoung higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT jeonsoojee higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT kimkyuyeun higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT limjeonghoon higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT jungheeyeon higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT choijiyoung higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT parksunhee higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT kimchanduck higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT kimyonglim higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients AT chojanghee higherserumtotalcholesteroltohighdensitylipoproteincholesterolratioisassociatedwithincreasedmortalityamongincidentperitonealdialysispatients |