An increase in glycoprotein concentration on extracellular virions dramatically alters vaccinia virus infectivity and pathogenesis without impacting immunogenicity

The extracellular virion (EV) form of Orthopoxviruses is required for cell-to-cell spread and pathogenesis, and is the target of neutralizing antibodies in the protective immune response. EV have a double envelope that contains several unique proteins that are involved in its intracellular envelopme...

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Detalles Bibliográficos
Autores principales: Monticelli, Stephanie R., Bryk, Peter, Brewer, Matthew G., Aguilar, Hector C., Norbury, Christopher C., Ward, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746760/
https://www.ncbi.nlm.nih.gov/pubmed/34962975
http://dx.doi.org/10.1371/journal.ppat.1010177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746760/
https://www.ncbi.nlm.nih.gov/pubmed/34962975
http://dx.doi.org/10.1371/journal.ppat.1010177

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