Parameter Reliability and Understanding Enzyme Function

Knowledge of the Michaelis–Menten parameters and their meaning in different circumstances is an essential prerequisite to understanding enzyme function and behaviour. The published literature contains an abundance of values reported for many enzymes. The problem concerns assessing the appropriatenes...

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Detalles Bibliográficos
Autores principales: McDonald, Andrew G., Tipton, Keith F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746786/
https://www.ncbi.nlm.nih.gov/pubmed/35011495
http://dx.doi.org/10.3390/molecules27010263
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author McDonald, Andrew G.
Tipton, Keith F.
author_facet McDonald, Andrew G.
Tipton, Keith F.
author_sort McDonald, Andrew G.
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description Knowledge of the Michaelis–Menten parameters and their meaning in different circumstances is an essential prerequisite to understanding enzyme function and behaviour. The published literature contains an abundance of values reported for many enzymes. The problem concerns assessing the appropriateness and validity of such material for the purpose to which it is to be applied. This review considers the evaluation of such data with particular emphasis on the assessment of its fitness for purpose.
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spelling pubmed-87467862022-01-11 Parameter Reliability and Understanding Enzyme Function McDonald, Andrew G. Tipton, Keith F. Molecules Review Knowledge of the Michaelis–Menten parameters and their meaning in different circumstances is an essential prerequisite to understanding enzyme function and behaviour. The published literature contains an abundance of values reported for many enzymes. The problem concerns assessing the appropriateness and validity of such material for the purpose to which it is to be applied. This review considers the evaluation of such data with particular emphasis on the assessment of its fitness for purpose. MDPI 2022-01-01 /pmc/articles/PMC8746786/ /pubmed/35011495 http://dx.doi.org/10.3390/molecules27010263 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McDonald, Andrew G.
Tipton, Keith F.
Parameter Reliability and Understanding Enzyme Function
title Parameter Reliability and Understanding Enzyme Function
title_full Parameter Reliability and Understanding Enzyme Function
title_fullStr Parameter Reliability and Understanding Enzyme Function
title_full_unstemmed Parameter Reliability and Understanding Enzyme Function
title_short Parameter Reliability and Understanding Enzyme Function
title_sort parameter reliability and understanding enzyme function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746786/
https://www.ncbi.nlm.nih.gov/pubmed/35011495
http://dx.doi.org/10.3390/molecules27010263
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