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Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index

A relationship between vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM) has been described. Considering that GDM prevalence depends on body mass index (BMI), our main objective was to determine if VDD is associated with GDM, independent of BMI. A cross-sectional study with 886 preg...

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Autores principales: Agüero-Domenech, Nuria, Jover, Silvia, Sarrión, Ana, Baranda, Javier, Quesada-Rico, José A., Pereira-Expósito, Avelino, Gil-Guillén, Vicente, Cortés-Castell, Ernesto, García-Teruel, María J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746839/
https://www.ncbi.nlm.nih.gov/pubmed/35010982
http://dx.doi.org/10.3390/nu14010102
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author Agüero-Domenech, Nuria
Jover, Silvia
Sarrión, Ana
Baranda, Javier
Quesada-Rico, José A.
Pereira-Expósito, Avelino
Gil-Guillén, Vicente
Cortés-Castell, Ernesto
García-Teruel, María J.
author_facet Agüero-Domenech, Nuria
Jover, Silvia
Sarrión, Ana
Baranda, Javier
Quesada-Rico, José A.
Pereira-Expósito, Avelino
Gil-Guillén, Vicente
Cortés-Castell, Ernesto
García-Teruel, María J.
author_sort Agüero-Domenech, Nuria
collection PubMed
description A relationship between vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM) has been described. Considering that GDM prevalence depends on body mass index (BMI), our main objective was to determine if VDD is associated with GDM, independent of BMI. A cross-sectional study with 886 pregnant women was conducted in Elda (Spain) from September 2019 to June 2020. To assess the association, Poisson regression models with robust variance were used to estimate the prevalence ratio (PR). The observed GDM prevalence was 10.5%, while the VDD prevalence was 55.5%. In the crude model, both VDD and obesity were associated with GDM, but in the adjusted model, only VDD was statistically significant (PR = 1.635, p = 0.038). A secondary event analysis did not detect differences in VDD, but BMI yielded a higher frequency of births by cesarean section and newborns with a >90 percentile weight in the obesity group. In conclusion, VDD is associated with GDM, independent of BMI. Future longitudinal studies could provide information on causality.
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spelling pubmed-87468392022-01-11 Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index Agüero-Domenech, Nuria Jover, Silvia Sarrión, Ana Baranda, Javier Quesada-Rico, José A. Pereira-Expósito, Avelino Gil-Guillén, Vicente Cortés-Castell, Ernesto García-Teruel, María J. Nutrients Article A relationship between vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM) has been described. Considering that GDM prevalence depends on body mass index (BMI), our main objective was to determine if VDD is associated with GDM, independent of BMI. A cross-sectional study with 886 pregnant women was conducted in Elda (Spain) from September 2019 to June 2020. To assess the association, Poisson regression models with robust variance were used to estimate the prevalence ratio (PR). The observed GDM prevalence was 10.5%, while the VDD prevalence was 55.5%. In the crude model, both VDD and obesity were associated with GDM, but in the adjusted model, only VDD was statistically significant (PR = 1.635, p = 0.038). A secondary event analysis did not detect differences in VDD, but BMI yielded a higher frequency of births by cesarean section and newborns with a >90 percentile weight in the obesity group. In conclusion, VDD is associated with GDM, independent of BMI. Future longitudinal studies could provide information on causality. MDPI 2021-12-27 /pmc/articles/PMC8746839/ /pubmed/35010982 http://dx.doi.org/10.3390/nu14010102 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Agüero-Domenech, Nuria
Jover, Silvia
Sarrión, Ana
Baranda, Javier
Quesada-Rico, José A.
Pereira-Expósito, Avelino
Gil-Guillén, Vicente
Cortés-Castell, Ernesto
García-Teruel, María J.
Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
title Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
title_full Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
title_fullStr Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
title_full_unstemmed Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
title_short Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
title_sort vitamin d deficiency and gestational diabetes mellitus in relation to body mass index
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746839/
https://www.ncbi.nlm.nih.gov/pubmed/35010982
http://dx.doi.org/10.3390/nu14010102
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