Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease

(68)Ga-DOTATATE is a well-established, positron-emitting, somatostatin receptor–binding radiopharmaceutical. We present an unusual case of transiently increased blood pool uptake of (68)Ga-DOTATATE in a patient with well-differentiated stage IV neuroendocrine tumor, with Ki-67 <2% (WHO grade 1) m...

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Detalles Bibliográficos
Autores principales: Sharma, Akash, Navaz, Anem J., Pandey, Mukesh K., Parent, Ephraim E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746921/
https://www.ncbi.nlm.nih.gov/pubmed/34690295
http://dx.doi.org/10.1097/RLU.0000000000003940
Descripción
Sumario:(68)Ga-DOTATATE is a well-established, positron-emitting, somatostatin receptor–binding radiopharmaceutical. We present an unusual case of transiently increased blood pool uptake of (68)Ga-DOTATATE in a patient with well-differentiated stage IV neuroendocrine tumor, with Ki-67 <2% (WHO grade 1) maintained on lanreotide. During serial (68)Ga-DOTATATE PET/CT examinations, increased blood pool accumulation of presumably unbound (68)Ga was demonstrated, which could impact the Kenning score and lead to a false treatment response assessment.

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