Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease

(68)Ga-DOTATATE is a well-established, positron-emitting, somatostatin receptor–binding radiopharmaceutical. We present an unusual case of transiently increased blood pool uptake of (68)Ga-DOTATATE in a patient with well-differentiated stage IV neuroendocrine tumor, with Ki-67 <2% (WHO grade 1) m...

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Autores principales: Sharma, Akash, Navaz, Anem J., Pandey, Mukesh K., Parent, Ephraim E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746921/
https://www.ncbi.nlm.nih.gov/pubmed/34690295
http://dx.doi.org/10.1097/RLU.0000000000003940
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author Sharma, Akash
Navaz, Anem J.
Pandey, Mukesh K.
Parent, Ephraim E.
author_facet Sharma, Akash
Navaz, Anem J.
Pandey, Mukesh K.
Parent, Ephraim E.
author_sort Sharma, Akash
collection PubMed
description (68)Ga-DOTATATE is a well-established, positron-emitting, somatostatin receptor–binding radiopharmaceutical. We present an unusual case of transiently increased blood pool uptake of (68)Ga-DOTATATE in a patient with well-differentiated stage IV neuroendocrine tumor, with Ki-67 <2% (WHO grade 1) maintained on lanreotide. During serial (68)Ga-DOTATATE PET/CT examinations, increased blood pool accumulation of presumably unbound (68)Ga was demonstrated, which could impact the Kenning score and lead to a false treatment response assessment.
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spelling pubmed-87469212022-01-14 Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease Sharma, Akash Navaz, Anem J. Pandey, Mukesh K. Parent, Ephraim E. Clin Nucl Med Interesting Images (68)Ga-DOTATATE is a well-established, positron-emitting, somatostatin receptor–binding radiopharmaceutical. We present an unusual case of transiently increased blood pool uptake of (68)Ga-DOTATATE in a patient with well-differentiated stage IV neuroendocrine tumor, with Ki-67 <2% (WHO grade 1) maintained on lanreotide. During serial (68)Ga-DOTATATE PET/CT examinations, increased blood pool accumulation of presumably unbound (68)Ga was demonstrated, which could impact the Kenning score and lead to a false treatment response assessment. Lippincott Williams & Wilkins 2022-02 2021-10-22 /pmc/articles/PMC8746921/ /pubmed/34690295 http://dx.doi.org/10.1097/RLU.0000000000003940 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Interesting Images
Sharma, Akash
Navaz, Anem J.
Pandey, Mukesh K.
Parent, Ephraim E.
Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease
title Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease
title_full Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease
title_fullStr Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease
title_full_unstemmed Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease
title_short Unusual Increased Blood Pool Activity on (68)Ga-DOTATATE PET/CT in a Patient With Metastatic Neuroendocrine Disease
title_sort unusual increased blood pool activity on (68)ga-dotatate pet/ct in a patient with metastatic neuroendocrine disease
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746921/
https://www.ncbi.nlm.nih.gov/pubmed/34690295
http://dx.doi.org/10.1097/RLU.0000000000003940
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