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Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients

Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to evaluate the potential links between serum metabolomics and...

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Autores principales: Leyrolle, Quentin, Cserjesi, Renata, Demeure, Romane, Neyrinck, Audrey M., Amadieu, Camille, Rodriguez, Julie, Kärkkäinen, Olli, Hanhineva, Kati, Paquot, Nicolas, Cnop, Miriam, Cani, Patrice D., Thissen, Jean-Paul, Bindels, Laure B., Klein, Olivier, Luminet, Olivier, Delzenne, Nathalie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746987/
https://www.ncbi.nlm.nih.gov/pubmed/35011021
http://dx.doi.org/10.3390/nu14010147
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author Leyrolle, Quentin
Cserjesi, Renata
Demeure, Romane
Neyrinck, Audrey M.
Amadieu, Camille
Rodriguez, Julie
Kärkkäinen, Olli
Hanhineva, Kati
Paquot, Nicolas
Cnop, Miriam
Cani, Patrice D.
Thissen, Jean-Paul
Bindels, Laure B.
Klein, Olivier
Luminet, Olivier
Delzenne, Nathalie M.
author_facet Leyrolle, Quentin
Cserjesi, Renata
Demeure, Romane
Neyrinck, Audrey M.
Amadieu, Camille
Rodriguez, Julie
Kärkkäinen, Olli
Hanhineva, Kati
Paquot, Nicolas
Cnop, Miriam
Cani, Patrice D.
Thissen, Jean-Paul
Bindels, Laure B.
Klein, Olivier
Luminet, Olivier
Delzenne, Nathalie M.
author_sort Leyrolle, Quentin
collection PubMed
description Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to evaluate the potential links between serum metabolomics and gut microbiome, and mood disturbances in a cohort of obese patients. Psychological, biological characteristics and nutritional habits were evaluated in 94 obese subjects from the Food4Gut study stratified according to their mood score assessed by the Positive and Negative Affect Schedule (PANAS). The fecal gut microbiota and plasma non-targeted metabolomics were analysed. Obese subjects with increased negative mood display elevated levels of Coprococcus as well as decreased levels of Sutterella and Lactobacillus. Serum metabolite profile analysis reveals in these subjects altered levels of several amino acid-derived metabolites, such as an increased level of L-histidine and a decreased in phenylacetylglutamine, linked to altered gut microbiota composition and function rather than to differences in dietary amino acid intake. Regarding clinical profile, we did not observe any differences between both groups. Our results reveal new microbiota-derived metabolites that characterize the alterations of mood in obese subjects, thereby allowing to propose new targets to tackle mood disturbances in this context. Food4gut, clinicaltrial.gov: NCT03852069.
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spelling pubmed-87469872022-01-11 Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients Leyrolle, Quentin Cserjesi, Renata Demeure, Romane Neyrinck, Audrey M. Amadieu, Camille Rodriguez, Julie Kärkkäinen, Olli Hanhineva, Kati Paquot, Nicolas Cnop, Miriam Cani, Patrice D. Thissen, Jean-Paul Bindels, Laure B. Klein, Olivier Luminet, Olivier Delzenne, Nathalie M. Nutrients Article Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to evaluate the potential links between serum metabolomics and gut microbiome, and mood disturbances in a cohort of obese patients. Psychological, biological characteristics and nutritional habits were evaluated in 94 obese subjects from the Food4Gut study stratified according to their mood score assessed by the Positive and Negative Affect Schedule (PANAS). The fecal gut microbiota and plasma non-targeted metabolomics were analysed. Obese subjects with increased negative mood display elevated levels of Coprococcus as well as decreased levels of Sutterella and Lactobacillus. Serum metabolite profile analysis reveals in these subjects altered levels of several amino acid-derived metabolites, such as an increased level of L-histidine and a decreased in phenylacetylglutamine, linked to altered gut microbiota composition and function rather than to differences in dietary amino acid intake. Regarding clinical profile, we did not observe any differences between both groups. Our results reveal new microbiota-derived metabolites that characterize the alterations of mood in obese subjects, thereby allowing to propose new targets to tackle mood disturbances in this context. Food4gut, clinicaltrial.gov: NCT03852069. MDPI 2021-12-29 /pmc/articles/PMC8746987/ /pubmed/35011021 http://dx.doi.org/10.3390/nu14010147 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leyrolle, Quentin
Cserjesi, Renata
Demeure, Romane
Neyrinck, Audrey M.
Amadieu, Camille
Rodriguez, Julie
Kärkkäinen, Olli
Hanhineva, Kati
Paquot, Nicolas
Cnop, Miriam
Cani, Patrice D.
Thissen, Jean-Paul
Bindels, Laure B.
Klein, Olivier
Luminet, Olivier
Delzenne, Nathalie M.
Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
title Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
title_full Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
title_fullStr Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
title_full_unstemmed Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
title_short Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
title_sort microbiota and metabolite profiling as markers of mood disorders: a cross-sectional study in obese patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746987/
https://www.ncbi.nlm.nih.gov/pubmed/35011021
http://dx.doi.org/10.3390/nu14010147
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