Cargando…

Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns

Background: Delayed onset of minimal enteral nutrition compromises the immune response of preterm infants, increasing the risk of colonization and clinical complications (e.g., late-onset sepsis). This study aimed to analyze associations between late-onset sepsis in very low birth weight infants (&l...

Descripción completa

Detalles Bibliográficos
Autores principales: de Sousa, Juliany Caroline Silva, de Carvalho, Ana Verônica Dantas, Monte de Prada, Lorena de Carvalho, Marinho, Arthur Pedro, de Lima, Kerolaynne Fonseca, Macedo, Suianny Karla de Oliveira, Santos, Camila Dayze Pereira, da Câmara, Saionara Maria Aires, Barreto, Anna Christina do Nascimento Granjeiro, Pereira, Silvana Alves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747100/
https://www.ncbi.nlm.nih.gov/pubmed/35011069
http://dx.doi.org/10.3390/nu14010196
_version_ 1784630749129867264
author de Sousa, Juliany Caroline Silva
de Carvalho, Ana Verônica Dantas
Monte de Prada, Lorena de Carvalho
Marinho, Arthur Pedro
de Lima, Kerolaynne Fonseca
Macedo, Suianny Karla de Oliveira
Santos, Camila Dayze Pereira
da Câmara, Saionara Maria Aires
Barreto, Anna Christina do Nascimento Granjeiro
Pereira, Silvana Alves
author_facet de Sousa, Juliany Caroline Silva
de Carvalho, Ana Verônica Dantas
Monte de Prada, Lorena de Carvalho
Marinho, Arthur Pedro
de Lima, Kerolaynne Fonseca
Macedo, Suianny Karla de Oliveira
Santos, Camila Dayze Pereira
da Câmara, Saionara Maria Aires
Barreto, Anna Christina do Nascimento Granjeiro
Pereira, Silvana Alves
author_sort de Sousa, Juliany Caroline Silva
collection PubMed
description Background: Delayed onset of minimal enteral nutrition compromises the immune response of preterm infants, increasing the risk of colonization and clinical complications (e.g., late-onset sepsis). This study aimed to analyze associations between late-onset sepsis in very low birth weight infants (<1500 g) and days of parenteral nutrition, days to reach full enteral nutrition, and maternal and nutritional factors. Methods: A cross-sectional study was carried out with very low birth weight infants admitted to a neonatal intensive care unit (NICU) of a reference maternity hospital of high-risk deliveries. Data regarding days of parenteral nutrition, days to reach full enteral nutrition, fasting days, extrauterine growth restriction, and NICU length of stay were extracted from online medical records. Late-onset sepsis was diagnosed (clinical or laboratory) after 48 h of life. Chi-squared, Mann–Whitney tests, and binary logistic regression were applied. Results: A total of 97 preterm infants were included. Of those, 75 presented late-onset sepsis with clinical (n = 40) or laboratory (n = 35) diagnosis. Maternal urinary tract infection, prolonged parenteral nutrition (>14 days), and extrauterine growth restriction presented 4.24-fold, 4.86-fold, and 4.90-fold higher chance of late-onset sepsis, respectively. Conclusion: Very low birth weight infants with late-onset sepsis had prolonged parenteral nutrition and took longer to reach full enteral nutrition. They also presented a higher prevalence of extrauterine growth restriction than infants without late-onset sepsis.
format Online
Article
Text
id pubmed-8747100
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87471002022-01-11 Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns de Sousa, Juliany Caroline Silva de Carvalho, Ana Verônica Dantas Monte de Prada, Lorena de Carvalho Marinho, Arthur Pedro de Lima, Kerolaynne Fonseca Macedo, Suianny Karla de Oliveira Santos, Camila Dayze Pereira da Câmara, Saionara Maria Aires Barreto, Anna Christina do Nascimento Granjeiro Pereira, Silvana Alves Nutrients Article Background: Delayed onset of minimal enteral nutrition compromises the immune response of preterm infants, increasing the risk of colonization and clinical complications (e.g., late-onset sepsis). This study aimed to analyze associations between late-onset sepsis in very low birth weight infants (<1500 g) and days of parenteral nutrition, days to reach full enteral nutrition, and maternal and nutritional factors. Methods: A cross-sectional study was carried out with very low birth weight infants admitted to a neonatal intensive care unit (NICU) of a reference maternity hospital of high-risk deliveries. Data regarding days of parenteral nutrition, days to reach full enteral nutrition, fasting days, extrauterine growth restriction, and NICU length of stay were extracted from online medical records. Late-onset sepsis was diagnosed (clinical or laboratory) after 48 h of life. Chi-squared, Mann–Whitney tests, and binary logistic regression were applied. Results: A total of 97 preterm infants were included. Of those, 75 presented late-onset sepsis with clinical (n = 40) or laboratory (n = 35) diagnosis. Maternal urinary tract infection, prolonged parenteral nutrition (>14 days), and extrauterine growth restriction presented 4.24-fold, 4.86-fold, and 4.90-fold higher chance of late-onset sepsis, respectively. Conclusion: Very low birth weight infants with late-onset sepsis had prolonged parenteral nutrition and took longer to reach full enteral nutrition. They also presented a higher prevalence of extrauterine growth restriction than infants without late-onset sepsis. MDPI 2021-12-31 /pmc/articles/PMC8747100/ /pubmed/35011069 http://dx.doi.org/10.3390/nu14010196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Sousa, Juliany Caroline Silva
de Carvalho, Ana Verônica Dantas
Monte de Prada, Lorena de Carvalho
Marinho, Arthur Pedro
de Lima, Kerolaynne Fonseca
Macedo, Suianny Karla de Oliveira
Santos, Camila Dayze Pereira
da Câmara, Saionara Maria Aires
Barreto, Anna Christina do Nascimento Granjeiro
Pereira, Silvana Alves
Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns
title Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns
title_full Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns
title_fullStr Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns
title_full_unstemmed Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns
title_short Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns
title_sort nutritional factors associated with late-onset sepsis in very low birth weight newborns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747100/
https://www.ncbi.nlm.nih.gov/pubmed/35011069
http://dx.doi.org/10.3390/nu14010196
work_keys_str_mv AT desousajulianycarolinesilva nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT decarvalhoanaveronicadantas nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT montedepradalorenadecarvalho nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT marinhoarthurpedro nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT delimakerolaynnefonseca nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT macedosuiannykarladeoliveira nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT santoscamiladayzepereira nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT dacamarasaionaramariaaires nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT barretoannachristinadonascimentogranjeiro nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns
AT pereirasilvanaalves nutritionalfactorsassociatedwithlateonsetsepsisinverylowbirthweightnewborns