Cargando…

How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review

Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopez Marquez, Alex, Gareis, Iván Emilio, Dias, Fernando José, Gerhard, Christoph, Lezcano, María Florencia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747153/
https://www.ncbi.nlm.nih.gov/pubmed/35012232
http://dx.doi.org/10.3390/polym14010209
_version_ 1784630762977361920
author Lopez Marquez, Alex
Gareis, Iván Emilio
Dias, Fernando José
Gerhard, Christoph
Lezcano, María Florencia
author_facet Lopez Marquez, Alex
Gareis, Iván Emilio
Dias, Fernando José
Gerhard, Christoph
Lezcano, María Florencia
author_sort Lopez Marquez, Alex
collection PubMed
description Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell–scaffold interactions. A systematic approach following PRISMA, GRADE, PICO, and other standard methodological frameworks for systematic reviews was used. Different topographic interventions and their effects on cell–scaffold interactions were analyzed. Results indicate that nanopores and roughness on fiber surfaces seem to improve proliferation and adhesion of cells. The quality of the evidence is different for each studied cell–scaffold interaction, and for each studied morphological attribute. The evidence points to improvements in cell–scaffold interactions on most morphologically complex fiber surfaces. The discussion includes an in-depth evaluation of the indirectness of the evidence, as well as the potentially involved publication bias. Insights and suggestions about dose-dependency relationship, as well as the effect on particular cell and polymer types, are presented. It is concluded that topographical alterations to the fiber surface should be further studied, since results so far are promising.
format Online
Article
Text
id pubmed-8747153
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87471532022-01-11 How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review Lopez Marquez, Alex Gareis, Iván Emilio Dias, Fernando José Gerhard, Christoph Lezcano, María Florencia Polymers (Basel) Review Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell–scaffold interactions. A systematic approach following PRISMA, GRADE, PICO, and other standard methodological frameworks for systematic reviews was used. Different topographic interventions and their effects on cell–scaffold interactions were analyzed. Results indicate that nanopores and roughness on fiber surfaces seem to improve proliferation and adhesion of cells. The quality of the evidence is different for each studied cell–scaffold interaction, and for each studied morphological attribute. The evidence points to improvements in cell–scaffold interactions on most morphologically complex fiber surfaces. The discussion includes an in-depth evaluation of the indirectness of the evidence, as well as the potentially involved publication bias. Insights and suggestions about dose-dependency relationship, as well as the effect on particular cell and polymer types, are presented. It is concluded that topographical alterations to the fiber surface should be further studied, since results so far are promising. MDPI 2022-01-05 /pmc/articles/PMC8747153/ /pubmed/35012232 http://dx.doi.org/10.3390/polym14010209 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lopez Marquez, Alex
Gareis, Iván Emilio
Dias, Fernando José
Gerhard, Christoph
Lezcano, María Florencia
How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
title How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
title_full How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
title_fullStr How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
title_full_unstemmed How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
title_short How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
title_sort how fiber surface topography affects interactions between cells and electrospun scaffolds: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747153/
https://www.ncbi.nlm.nih.gov/pubmed/35012232
http://dx.doi.org/10.3390/polym14010209
work_keys_str_mv AT lopezmarquezalex howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview
AT gareisivanemilio howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview
AT diasfernandojose howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview
AT gerhardchristoph howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview
AT lezcanomariaflorencia howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview