Cargando…
How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747153/ https://www.ncbi.nlm.nih.gov/pubmed/35012232 http://dx.doi.org/10.3390/polym14010209 |
_version_ | 1784630762977361920 |
---|---|
author | Lopez Marquez, Alex Gareis, Iván Emilio Dias, Fernando José Gerhard, Christoph Lezcano, María Florencia |
author_facet | Lopez Marquez, Alex Gareis, Iván Emilio Dias, Fernando José Gerhard, Christoph Lezcano, María Florencia |
author_sort | Lopez Marquez, Alex |
collection | PubMed |
description | Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell–scaffold interactions. A systematic approach following PRISMA, GRADE, PICO, and other standard methodological frameworks for systematic reviews was used. Different topographic interventions and their effects on cell–scaffold interactions were analyzed. Results indicate that nanopores and roughness on fiber surfaces seem to improve proliferation and adhesion of cells. The quality of the evidence is different for each studied cell–scaffold interaction, and for each studied morphological attribute. The evidence points to improvements in cell–scaffold interactions on most morphologically complex fiber surfaces. The discussion includes an in-depth evaluation of the indirectness of the evidence, as well as the potentially involved publication bias. Insights and suggestions about dose-dependency relationship, as well as the effect on particular cell and polymer types, are presented. It is concluded that topographical alterations to the fiber surface should be further studied, since results so far are promising. |
format | Online Article Text |
id | pubmed-8747153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87471532022-01-11 How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review Lopez Marquez, Alex Gareis, Iván Emilio Dias, Fernando José Gerhard, Christoph Lezcano, María Florencia Polymers (Basel) Review Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell–scaffold interactions. A systematic approach following PRISMA, GRADE, PICO, and other standard methodological frameworks for systematic reviews was used. Different topographic interventions and their effects on cell–scaffold interactions were analyzed. Results indicate that nanopores and roughness on fiber surfaces seem to improve proliferation and adhesion of cells. The quality of the evidence is different for each studied cell–scaffold interaction, and for each studied morphological attribute. The evidence points to improvements in cell–scaffold interactions on most morphologically complex fiber surfaces. The discussion includes an in-depth evaluation of the indirectness of the evidence, as well as the potentially involved publication bias. Insights and suggestions about dose-dependency relationship, as well as the effect on particular cell and polymer types, are presented. It is concluded that topographical alterations to the fiber surface should be further studied, since results so far are promising. MDPI 2022-01-05 /pmc/articles/PMC8747153/ /pubmed/35012232 http://dx.doi.org/10.3390/polym14010209 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lopez Marquez, Alex Gareis, Iván Emilio Dias, Fernando José Gerhard, Christoph Lezcano, María Florencia How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review |
title | How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review |
title_full | How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review |
title_fullStr | How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review |
title_full_unstemmed | How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review |
title_short | How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review |
title_sort | how fiber surface topography affects interactions between cells and electrospun scaffolds: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747153/ https://www.ncbi.nlm.nih.gov/pubmed/35012232 http://dx.doi.org/10.3390/polym14010209 |
work_keys_str_mv | AT lopezmarquezalex howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview AT gareisivanemilio howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview AT diasfernandojose howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview AT gerhardchristoph howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview AT lezcanomariaflorencia howfibersurfacetopographyaffectsinteractionsbetweencellsandelectrospunscaffoldsasystematicreview |