Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors...

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Autores principales: Krasikov, Valerii D., Santuryan, Yulia G., Malahova, Irina I., Ivanov, Alexey G., Gorshkov, Nikolay I., Panarin, Evgenii F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747385/
https://www.ncbi.nlm.nih.gov/pubmed/35012128
http://dx.doi.org/10.3390/polym14010105
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author Krasikov, Valerii D.
Santuryan, Yulia G.
Malahova, Irina I.
Ivanov, Alexey G.
Gorshkov, Nikolay I.
Panarin, Evgenii F.
author_facet Krasikov, Valerii D.
Santuryan, Yulia G.
Malahova, Irina I.
Ivanov, Alexey G.
Gorshkov, Nikolay I.
Panarin, Evgenii F.
author_sort Krasikov, Valerii D.
collection PubMed
description Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.
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spelling pubmed-87473852022-01-11 Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy Krasikov, Valerii D. Santuryan, Yulia G. Malahova, Irina I. Ivanov, Alexey G. Gorshkov, Nikolay I. Panarin, Evgenii F. Polymers (Basel) Article Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage. MDPI 2021-12-28 /pmc/articles/PMC8747385/ /pubmed/35012128 http://dx.doi.org/10.3390/polym14010105 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krasikov, Valerii D.
Santuryan, Yulia G.
Malahova, Irina I.
Ivanov, Alexey G.
Gorshkov, Nikolay I.
Panarin, Evgenii F.
Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy
title Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy
title_full Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy
title_fullStr Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy
title_full_unstemmed Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy
title_short Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy
title_sort complexes of glucarolactones with water-soluble copolymers of n-vinylpyrrolidone with n-vinylamine as inhibitors of β-glucuronidase efficacy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747385/
https://www.ncbi.nlm.nih.gov/pubmed/35012128
http://dx.doi.org/10.3390/polym14010105
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