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A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls

Until now, clinicians are not able to evaluate the Psychogenic Non-Epileptic Seizures (PNES) from the rest-electroencephalography (EEG) readout. No EEG marker can help differentiate PNES cases from healthy subjects. In this paper, we have investigated the power spectrum density (PSD), in resting-sta...

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Autores principales: Varone, Giuseppe, Boulila, Wadii, Lo Giudice, Michele, Benjdira, Bilel, Mammone, Nadia, Ieracitano, Cosimo, Dashtipour, Kia, Neri, Sabrina, Gasparini, Sara, Morabito, Francesco Carlo, Hussain, Amir, Aguglia, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747462/
https://www.ncbi.nlm.nih.gov/pubmed/35009675
http://dx.doi.org/10.3390/s22010129
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author Varone, Giuseppe
Boulila, Wadii
Lo Giudice, Michele
Benjdira, Bilel
Mammone, Nadia
Ieracitano, Cosimo
Dashtipour, Kia
Neri, Sabrina
Gasparini, Sara
Morabito, Francesco Carlo
Hussain, Amir
Aguglia, Umberto
author_facet Varone, Giuseppe
Boulila, Wadii
Lo Giudice, Michele
Benjdira, Bilel
Mammone, Nadia
Ieracitano, Cosimo
Dashtipour, Kia
Neri, Sabrina
Gasparini, Sara
Morabito, Francesco Carlo
Hussain, Amir
Aguglia, Umberto
author_sort Varone, Giuseppe
collection PubMed
description Until now, clinicians are not able to evaluate the Psychogenic Non-Epileptic Seizures (PNES) from the rest-electroencephalography (EEG) readout. No EEG marker can help differentiate PNES cases from healthy subjects. In this paper, we have investigated the power spectrum density (PSD), in resting-state EEGs, to evaluate the abnormalities in PNES affected brains. Additionally, we have used functional connectivity tools, such as phase lag index (PLI), and graph-derived metrics to better observe the integration of distributed information of regular and synchronized multi-scale communication within and across inter-regional brain areas. We proved the utility of our method after enrolling a cohort study of 20 age- and gender-matched PNES and 19 healthy control (HC) subjects. In this work, three classification models, namely support vector machine (SVM), linear discriminant analysis (LDA), and Multilayer perceptron (MLP), have been employed to model the relationship between the functional connectivity features (rest-HC versus rest-PNES). The best performance for the discrimination of participants was obtained using the MLP classifier, reporting a precision of 85.73%, a recall of 86.57%, an F1-score of 78.98%, and, finally, an accuracy of 91.02%. In conclusion, our results hypothesized two main aspects. The first is an intrinsic organization of functional brain networks that reflects a dysfunctional level of integration across brain regions, which can provide new insights into the pathophysiological mechanisms of PNES. The second is that functional connectivity features and MLP could be a promising method to classify rest-EEG data of PNES form healthy controls subjects.
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spelling pubmed-87474622022-01-11 A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls Varone, Giuseppe Boulila, Wadii Lo Giudice, Michele Benjdira, Bilel Mammone, Nadia Ieracitano, Cosimo Dashtipour, Kia Neri, Sabrina Gasparini, Sara Morabito, Francesco Carlo Hussain, Amir Aguglia, Umberto Sensors (Basel) Article Until now, clinicians are not able to evaluate the Psychogenic Non-Epileptic Seizures (PNES) from the rest-electroencephalography (EEG) readout. No EEG marker can help differentiate PNES cases from healthy subjects. In this paper, we have investigated the power spectrum density (PSD), in resting-state EEGs, to evaluate the abnormalities in PNES affected brains. Additionally, we have used functional connectivity tools, such as phase lag index (PLI), and graph-derived metrics to better observe the integration of distributed information of regular and synchronized multi-scale communication within and across inter-regional brain areas. We proved the utility of our method after enrolling a cohort study of 20 age- and gender-matched PNES and 19 healthy control (HC) subjects. In this work, three classification models, namely support vector machine (SVM), linear discriminant analysis (LDA), and Multilayer perceptron (MLP), have been employed to model the relationship between the functional connectivity features (rest-HC versus rest-PNES). The best performance for the discrimination of participants was obtained using the MLP classifier, reporting a precision of 85.73%, a recall of 86.57%, an F1-score of 78.98%, and, finally, an accuracy of 91.02%. In conclusion, our results hypothesized two main aspects. The first is an intrinsic organization of functional brain networks that reflects a dysfunctional level of integration across brain regions, which can provide new insights into the pathophysiological mechanisms of PNES. The second is that functional connectivity features and MLP could be a promising method to classify rest-EEG data of PNES form healthy controls subjects. MDPI 2021-12-25 /pmc/articles/PMC8747462/ /pubmed/35009675 http://dx.doi.org/10.3390/s22010129 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Varone, Giuseppe
Boulila, Wadii
Lo Giudice, Michele
Benjdira, Bilel
Mammone, Nadia
Ieracitano, Cosimo
Dashtipour, Kia
Neri, Sabrina
Gasparini, Sara
Morabito, Francesco Carlo
Hussain, Amir
Aguglia, Umberto
A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls
title A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls
title_full A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls
title_fullStr A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls
title_full_unstemmed A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls
title_short A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls
title_sort machine learning approach involving functional connectivity features to classify rest-eeg psychogenic non-epileptic seizures from healthy controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747462/
https://www.ncbi.nlm.nih.gov/pubmed/35009675
http://dx.doi.org/10.3390/s22010129
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