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Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)

Background: Men and women with valvular heart disease have different risk profiles for clinical endpoints. Non-esterified fatty acids (NEFA) are possibly involved in cardio-metabolic disease. However, it is unclear whether NEFA concentrations are associated with physical performance in patients unde...

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Autores principales: Härdrich, Michaela, Haase-Fielitz, Anja, Fielitz, Jens, Boschmann, Michael, Pivovarova-Ramich, Olga, Pfeiffer, Andreas F. H., Rudovich, Natalia, Weylandt, Karsten H., Butter, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747609/
https://www.ncbi.nlm.nih.gov/pubmed/35011078
http://dx.doi.org/10.3390/nu14010203
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author Härdrich, Michaela
Haase-Fielitz, Anja
Fielitz, Jens
Boschmann, Michael
Pivovarova-Ramich, Olga
Pfeiffer, Andreas F. H.
Rudovich, Natalia
Weylandt, Karsten H.
Butter, Christian
author_facet Härdrich, Michaela
Haase-Fielitz, Anja
Fielitz, Jens
Boschmann, Michael
Pivovarova-Ramich, Olga
Pfeiffer, Andreas F. H.
Rudovich, Natalia
Weylandt, Karsten H.
Butter, Christian
author_sort Härdrich, Michaela
collection PubMed
description Background: Men and women with valvular heart disease have different risk profiles for clinical endpoints. Non-esterified fatty acids (NEFA) are possibly involved in cardio-metabolic disease. However, it is unclear whether NEFA concentrations are associated with physical performance in patients undergoing transcatheter aortic valve implantation (TAVI) and whether there are sex-specific effects. Methods: To test the hypothesis that NEFA concentration is associated with sex-specific physical performance, we prospectively analysed data from one hundred adult patients undergoing TAVI. NEFA concentrations, physical performance and anthropometric parameters were measured before and 6 and 12 months after TAVI. Physical performance was determined by a six-minute walking test (6-MWT) and self-reported weekly bicycle riding time. Results: Before TAVI, NEFA concentrations were higher in patients (44 women, 56 men) compared to the normal population. Median NEFA concentrations at 6 and 12 months after TAVI were within the reference range reported in the normal population in men but not women. Men but not women presented with an increased performance in the 6-MWT over time (p = 0.026, p = 0.142, respectively). Additionally, men showed an increased ability to ride a bicycle after TAVI compared to before TAVI (p = 0.034). NEFA concentrations before TAVI correlated with the 6-MWT before TAVI in women (Spearman’s rho −0.552; p = 0.001) but not in men (Spearman’s rho −0.007; p = 0.964). No association was found between NEFA concentrations and physical performance 6 and 12 months after TAVI. Conclusions: NEFA concentrations improved into the reference range in men but not women after TAVI. Men but not women have an increased physical performance after TAVI. No association between NEFA and physical performance was observed in men and women after TAVI.
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spelling pubmed-87476092022-01-11 Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI) Härdrich, Michaela Haase-Fielitz, Anja Fielitz, Jens Boschmann, Michael Pivovarova-Ramich, Olga Pfeiffer, Andreas F. H. Rudovich, Natalia Weylandt, Karsten H. Butter, Christian Nutrients Article Background: Men and women with valvular heart disease have different risk profiles for clinical endpoints. Non-esterified fatty acids (NEFA) are possibly involved in cardio-metabolic disease. However, it is unclear whether NEFA concentrations are associated with physical performance in patients undergoing transcatheter aortic valve implantation (TAVI) and whether there are sex-specific effects. Methods: To test the hypothesis that NEFA concentration is associated with sex-specific physical performance, we prospectively analysed data from one hundred adult patients undergoing TAVI. NEFA concentrations, physical performance and anthropometric parameters were measured before and 6 and 12 months after TAVI. Physical performance was determined by a six-minute walking test (6-MWT) and self-reported weekly bicycle riding time. Results: Before TAVI, NEFA concentrations were higher in patients (44 women, 56 men) compared to the normal population. Median NEFA concentrations at 6 and 12 months after TAVI were within the reference range reported in the normal population in men but not women. Men but not women presented with an increased performance in the 6-MWT over time (p = 0.026, p = 0.142, respectively). Additionally, men showed an increased ability to ride a bicycle after TAVI compared to before TAVI (p = 0.034). NEFA concentrations before TAVI correlated with the 6-MWT before TAVI in women (Spearman’s rho −0.552; p = 0.001) but not in men (Spearman’s rho −0.007; p = 0.964). No association was found between NEFA concentrations and physical performance 6 and 12 months after TAVI. Conclusions: NEFA concentrations improved into the reference range in men but not women after TAVI. Men but not women have an increased physical performance after TAVI. No association between NEFA and physical performance was observed in men and women after TAVI. MDPI 2022-01-02 /pmc/articles/PMC8747609/ /pubmed/35011078 http://dx.doi.org/10.3390/nu14010203 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Härdrich, Michaela
Haase-Fielitz, Anja
Fielitz, Jens
Boschmann, Michael
Pivovarova-Ramich, Olga
Pfeiffer, Andreas F. H.
Rudovich, Natalia
Weylandt, Karsten H.
Butter, Christian
Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)
title Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)
title_full Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)
title_fullStr Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)
title_full_unstemmed Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)
title_short Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI)
title_sort physical performance and non-esterified fatty acids in men and women after transcatheter aortic valve implantation (tavi)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747609/
https://www.ncbi.nlm.nih.gov/pubmed/35011078
http://dx.doi.org/10.3390/nu14010203
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