Cargando…
Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels
The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747654/ https://www.ncbi.nlm.nih.gov/pubmed/35012155 http://dx.doi.org/10.3390/polym14010130 |
_version_ | 1784630880289947648 |
---|---|
author | Bercea, Maria |
author_facet | Bercea, Maria |
author_sort | Bercea, Maria |
collection | PubMed |
description | The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA unfolding. By applying three successive freezing/thawing cycles, a stable porous network structure with elastic properties is designed, as evidenced by SEM and rheology. The hydrogels exhibit self-healing properties when the samples are cut into two pieces; the intermolecular interactions are reestablished in time and therefore the fragments repair themselves. The effects of the BSA content, loaded deformation and temperature on the self-healing ability of hydrogels are presented and discussed through rheological data. Due to their versatile viscoelastic behavior, the properties of PVA/HPC/BSA hydrogels can be tuned during their preparation in order to achieve suitable biomaterials for targeted applications. |
format | Online Article Text |
id | pubmed-8747654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87476542022-01-11 Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels Bercea, Maria Polymers (Basel) Article The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA unfolding. By applying three successive freezing/thawing cycles, a stable porous network structure with elastic properties is designed, as evidenced by SEM and rheology. The hydrogels exhibit self-healing properties when the samples are cut into two pieces; the intermolecular interactions are reestablished in time and therefore the fragments repair themselves. The effects of the BSA content, loaded deformation and temperature on the self-healing ability of hydrogels are presented and discussed through rheological data. Due to their versatile viscoelastic behavior, the properties of PVA/HPC/BSA hydrogels can be tuned during their preparation in order to achieve suitable biomaterials for targeted applications. MDPI 2021-12-30 /pmc/articles/PMC8747654/ /pubmed/35012155 http://dx.doi.org/10.3390/polym14010130 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bercea, Maria Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels |
title | Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels |
title_full | Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels |
title_fullStr | Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels |
title_full_unstemmed | Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels |
title_short | Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels |
title_sort | self-healing behavior of polymer/protein hybrid hydrogels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747654/ https://www.ncbi.nlm.nih.gov/pubmed/35012155 http://dx.doi.org/10.3390/polym14010130 |
work_keys_str_mv | AT berceamaria selfhealingbehaviorofpolymerproteinhybridhydrogels |