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No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants
PURPOSE: The role of splenic emptying in O(2) transport during aerobic exercise still remains a matter of debate. Our study compared the differences in spleen volume changes between aerobically trained and untrained individuals during step-transition supine cycling exercise at moderate-intensity. We...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747858/ https://www.ncbi.nlm.nih.gov/pubmed/35013810 http://dx.doi.org/10.1007/s00421-021-04843-w |
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author | Zubac, Damir Obad, Ante Šupe-Domić, Daniela Bošnjak, Ana Zec, Mirela Ivančev, Vladimir Valić, Zoran |
author_facet | Zubac, Damir Obad, Ante Šupe-Domić, Daniela Bošnjak, Ana Zec, Mirela Ivančev, Vladimir Valić, Zoran |
author_sort | Zubac, Damir |
collection | PubMed |
description | PURPOSE: The role of splenic emptying in O(2) transport during aerobic exercise still remains a matter of debate. Our study compared the differences in spleen volume changes between aerobically trained and untrained individuals during step-transition supine cycling exercise at moderate-intensity. We also examined the relationship between spleen volume changes, erythrocyte release, and O(2) uptake parameters. METHODS: Fourteen healthy men completed all study procedures, including a detailed medical examination, supine maximal O(2) uptake ([Formula: see text] max.) test, and three step-transitions from 20 W to a moderate-intensity power output, equivalent to [Formula: see text] uptake at 90% gas exchange threshold. During these step-transitions pulmonary [Formula: see text] , near-infrared spectroscopy of the vastus lateralis, and cardiovascular responses were continuously measured. In parallel, minute-by-minute ultrasonic measurements of the spleen were performed. Blood samples were taken before and immediately after step-transition cycling. RESULTS: On average, [Formula: see text] max. was 10 mL kg min(−1) (p = 0.001) higher in trained compared to their aerobically untrained peers. In response to supine step-transition cycling, the splenic volume was significantly reduced, and the largest reduction (~ 106 to 115 mL, ~ 38%, p = 0.001) was similar in both aerobically trained and untrained individuals. Erythrocyte concentration and platelet count transiently increased after exercise cessation, with no differences observed between groups. However, the vastus lateralis deoxygenation amplitude was 30% (p = 0.001) greater in trained compared to untrained individuals. No associations existed between: (i) spleen volumes at rest (ii) spleen volume changes (%), (iii) resting hematocrit and oxygen uptake parameters. CONCLUSION: Greater splenic emptying and subsequent erythrocyte release do not lead to a slower [Formula: see text] , regardless of individual [Formula: see text] max. readings. |
format | Online Article Text |
id | pubmed-8747858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-87478582022-01-11 No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants Zubac, Damir Obad, Ante Šupe-Domić, Daniela Bošnjak, Ana Zec, Mirela Ivančev, Vladimir Valić, Zoran Eur J Appl Physiol Original Article PURPOSE: The role of splenic emptying in O(2) transport during aerobic exercise still remains a matter of debate. Our study compared the differences in spleen volume changes between aerobically trained and untrained individuals during step-transition supine cycling exercise at moderate-intensity. We also examined the relationship between spleen volume changes, erythrocyte release, and O(2) uptake parameters. METHODS: Fourteen healthy men completed all study procedures, including a detailed medical examination, supine maximal O(2) uptake ([Formula: see text] max.) test, and three step-transitions from 20 W to a moderate-intensity power output, equivalent to [Formula: see text] uptake at 90% gas exchange threshold. During these step-transitions pulmonary [Formula: see text] , near-infrared spectroscopy of the vastus lateralis, and cardiovascular responses were continuously measured. In parallel, minute-by-minute ultrasonic measurements of the spleen were performed. Blood samples were taken before and immediately after step-transition cycling. RESULTS: On average, [Formula: see text] max. was 10 mL kg min(−1) (p = 0.001) higher in trained compared to their aerobically untrained peers. In response to supine step-transition cycling, the splenic volume was significantly reduced, and the largest reduction (~ 106 to 115 mL, ~ 38%, p = 0.001) was similar in both aerobically trained and untrained individuals. Erythrocyte concentration and platelet count transiently increased after exercise cessation, with no differences observed between groups. However, the vastus lateralis deoxygenation amplitude was 30% (p = 0.001) greater in trained compared to untrained individuals. No associations existed between: (i) spleen volumes at rest (ii) spleen volume changes (%), (iii) resting hematocrit and oxygen uptake parameters. CONCLUSION: Greater splenic emptying and subsequent erythrocyte release do not lead to a slower [Formula: see text] , regardless of individual [Formula: see text] max. readings. Springer Berlin Heidelberg 2022-01-11 2022 /pmc/articles/PMC8747858/ /pubmed/35013810 http://dx.doi.org/10.1007/s00421-021-04843-w Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021, corrected publication 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Zubac, Damir Obad, Ante Šupe-Domić, Daniela Bošnjak, Ana Zec, Mirela Ivančev, Vladimir Valić, Zoran No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
title | No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
title_full | No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
title_fullStr | No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
title_full_unstemmed | No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
title_short | No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
title_sort | no differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747858/ https://www.ncbi.nlm.nih.gov/pubmed/35013810 http://dx.doi.org/10.1007/s00421-021-04843-w |
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