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Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions

Objectives Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mi...

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Autores principales: Wetzk, Michelle, Grübling, Nannette, Forberger, Almuth, Klengel, Jörg, Kuhlmann, Jan Dominik, Wimberger, Pauline, Goeckenjan, Maren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747893/
https://www.ncbi.nlm.nih.gov/pubmed/35027863
http://dx.doi.org/10.1055/a-1580-0601
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author Wetzk, Michelle
Grübling, Nannette
Forberger, Almuth
Klengel, Jörg
Kuhlmann, Jan Dominik
Wimberger, Pauline
Goeckenjan, Maren
author_facet Wetzk, Michelle
Grübling, Nannette
Forberger, Almuth
Klengel, Jörg
Kuhlmann, Jan Dominik
Wimberger, Pauline
Goeckenjan, Maren
author_sort Wetzk, Michelle
collection PubMed
description Objectives Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mitotic rate in endometriotic lesions still remains to be elucidated. Methods In this retrospective study, the mitotic rates and clinical data of 542 patients with histologically diagnosed endometriosis were analyzed. The mean patient age was 33.5 ± 8.0 (17 – 72) years, and the mean reproductive lifespan was 21.2 ± 7.8 (4 – 41) years. Patients were divided into two groups and patientsʼ reproductive history and clinical endometriosis characteristics were compared between groups. The study group consisted of women with confirmed mitotic figures (n = 140, 25.83%) and the control group comprised women without proliferative activity according to their mitotic rates (n = 402, 74.27%). Results Women with endometriotic lesions and histologically confirmed mitotic figures were significantly more likely to have a higher endometriosis stage (p = 0.001), deep infiltrating endometriosis (p < 0.001), ovarian endometrioma (p = 0.012), and infertility (p = 0.049). A mitotic rate > 0 was seen significantly less often in cases with incidental findings of endometriosis (p = 0.031). The presence of symptoms and basic characteristics such as age, age at onset of menarche, reproductive lifespan and parity did not differ between the group with and the group without mitotic figures. Conclusion This study shows that a simple histological assessment of the mitotic rate offers additional diagnostic value for the detection of advanced stages of endometriosis. The possible role as a predictive marker for the recurrence of endometriosis or the development of endometriosis-associated cancer will require future study.
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spelling pubmed-87478932022-01-12 Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions Wetzk, Michelle Grübling, Nannette Forberger, Almuth Klengel, Jörg Kuhlmann, Jan Dominik Wimberger, Pauline Goeckenjan, Maren Geburtshilfe Frauenheilkd Objectives Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mitotic rate in endometriotic lesions still remains to be elucidated. Methods In this retrospective study, the mitotic rates and clinical data of 542 patients with histologically diagnosed endometriosis were analyzed. The mean patient age was 33.5 ± 8.0 (17 – 72) years, and the mean reproductive lifespan was 21.2 ± 7.8 (4 – 41) years. Patients were divided into two groups and patientsʼ reproductive history and clinical endometriosis characteristics were compared between groups. The study group consisted of women with confirmed mitotic figures (n = 140, 25.83%) and the control group comprised women without proliferative activity according to their mitotic rates (n = 402, 74.27%). Results Women with endometriotic lesions and histologically confirmed mitotic figures were significantly more likely to have a higher endometriosis stage (p = 0.001), deep infiltrating endometriosis (p < 0.001), ovarian endometrioma (p = 0.012), and infertility (p = 0.049). A mitotic rate > 0 was seen significantly less often in cases with incidental findings of endometriosis (p = 0.031). The presence of symptoms and basic characteristics such as age, age at onset of menarche, reproductive lifespan and parity did not differ between the group with and the group without mitotic figures. Conclusion This study shows that a simple histological assessment of the mitotic rate offers additional diagnostic value for the detection of advanced stages of endometriosis. The possible role as a predictive marker for the recurrence of endometriosis or the development of endometriosis-associated cancer will require future study. Georg Thieme Verlag KG 2022-01-10 /pmc/articles/PMC8747893/ /pubmed/35027863 http://dx.doi.org/10.1055/a-1580-0601 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Wetzk, Michelle
Grübling, Nannette
Forberger, Almuth
Klengel, Jörg
Kuhlmann, Jan Dominik
Wimberger, Pauline
Goeckenjan, Maren
Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
title Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
title_full Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
title_fullStr Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
title_full_unstemmed Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
title_short Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
title_sort diagnostic benefit of the detection of mitotic figures in endometriotic lesions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747893/
https://www.ncbi.nlm.nih.gov/pubmed/35027863
http://dx.doi.org/10.1055/a-1580-0601
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