Cargando…

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may target epitopes that reduce durability or increase the potential for escape from vaccine-induced immunity. Using synthetic vaccinology, we have developed rationally immune-focused SARS-CoV-2 Spike-based vaccines. Glycans can b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Konrath, Kylie M., Liaw, Kevin, Wu, Yuanhan, Zhu, Xizhou, Walker, Susanne N., Xu, Ziyang, Schultheis, Katherine, Chokkalingam, Neethu, Chawla, Himanshi, Du, Jianqiu, Tursi, Nicholas J., Moore, Alan, Adolf-Bryfogle, Jared, Purwar, Mansi, Reuschel, Emma L., Frase, Drew, Sullivan, Matthew, Fry, Benjamin, Maricic, Igor, Andrade, Viviane M., Iffland, Christel, Crispin, Max, Broderick, Kate E., Humeau, Laurent M.P.F., Patel, Ami, Smith, Trevor R.F., Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747942/ https://www.ncbi.nlm.nih.gov/pubmed/35090597 http://dx.doi.org/10.1016/j.celrep.2022.110318

Ejemplares similares

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer
por: Xu, Ziyang, et al.
Publicado: (2022)

SARS-CoV-2 Assays To Detect Functional Antibody Responses That Block ACE2 Recognition in Vaccinated Animals and Infected Patients
por: Walker, Susanne N., et al.
Publicado: (2020)

Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo
por: Tursi, Nicholas J., et al.
Publicado: (2023)

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates
por: Walters, Jewell N., et al.
Publicado: (2022)

DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2
por: Parzych, Elizabeth M., et al.
Publicado: (2022)

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020)
por: Xu, Ziyang, et al.
Publicado: (2020)

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity
por: Xu, Ziyang, et al.
Publicado: (2020)

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model
por: Patel, Ami, et al.
Publicado: (2021)

Incorporation of a Novel CD4+ Helper Epitope Identified from Aquifex aeolicus Enhances Humoral Responses Induced by DNA and Protein Vaccinations
por: Xu, Ziyang, et al.
Publicado: (2020)

Harnessing Recent Advances in Synthetic DNA and Electroporation Technologies for Rapid Vaccine Development Against COVID-19 and Other Emerging Infectious Diseases
por: Xu, Ziyang, et al.
Publicado: (2020)

Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo
por: Gary, Ebony N., et al.
Publicado: (2022)

Immunogenicity of a DNA vaccine candidate for COVID-19
por: Smith, Trevor R. F., et al.
Publicado: (2020)

Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin
por: Schultheis, Katherine, et al.
Publicado: (2016)

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation
por: Schommer, Nina N., et al.
Publicado: (2019)

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial
por: Tebas, Pablo, et al.
Publicado: (2020)

Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein
por: Bordoloi, Devivasha, et al.
Publicado: (2021)

578. INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants
por: Andrade, Viviane M, et al.
Publicado: (2021)

571. Safety and Immunogenicity of INO-4800, a COVID-19 DNA Vaccine as a Primary Series and Booster
por: Tebas, Pablo, et al.
Publicado: (2021)

INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants
por: Andrade, Viviane M., et al.
Publicado: (2021)

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model
por: Reeder, Sophia M., et al.
Publicado: (2020)

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques
por: Jiang, Jingjing, et al.
Publicado: (2019)

Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine
por: Guibinga, Ghiabe H., et al.
Publicado: (2020)

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo
por: Khoshnejad, Makan, et al.
Publicado: (2020)

A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy
por: Bordoloi, Devivasha, et al.
Publicado: (2022)

Principles of SARS-CoV-2 glycosylation
por: Chawla, Himanshi, et al.
Publicado: (2022)

579. Design and Immunogenicity of a Pan-SARS-CoV-2 Synthetic DNA Vaccine
por: Schultheis, Katherine, et al.
Publicado: (2021)

A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens
por: Gary, Ebony N., et al.
Publicado: (2021)

Nucleic acid-based vaccines targeting respiratory syncytial virus: Delivering the goods
por: Smith, Trevor R. F., et al.
Publicado: (2017)

P195: Orthopedic surgical infections caused by rapidly growing mycobacteria: integrative review of literature
por: Turrini, RNT, et al.
Publicado: (2013)

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response
por: Smith, Trevor RF, et al.
Publicado: (2014)

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity
por: Schultheis, Katherine, et al.
Publicado: (2020)

Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus
por: Patel, Ami, et al.
Publicado: (2021)

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model
por: Tursi, Nicholas J., et al.
Publicado: (2022)

The PyRosetta Toolkit: A Graphical User Interface for the Rosetta Software Suite
por: Adolf-Bryfogle, Jared, et al.
Publicado: (2013)

Subtle Influence of ACE2 Glycan Processing on SARS-CoV-2 Recognition
por: Allen, Joel D., et al.
Publicado: (2021)

Emotional Intelligence for Sales Success
por: Konrath, Jill
Publicado: (2012)

DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas
por: Zhu, Xizhou, et al.
Publicado: (2021)

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
por: Iffland, Kerstin, et al.
Publicado: (2017)

Varying Cognitive Scars – Differential Associations Between Types of Childhood Maltreatment and Facial Emotion Processing
por: Iffland, Benjamin, et al.
Publicado: (2020)

Peer Victimization Influences Attention Processing Beyond the Effects of Childhood Maltreatment by Caregivers
por: Iffland, Benjamin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ar5nvo3kqu976jk7crdtibp8ql